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Showing 1–9 of 9 results
Advanced filters: Author: Rhys P. D. Inward Clear advanced filters

  • Here, Isaacs, Nieto and Zhang et al. discover a potent nanobody and engineer a dual-action antibody that targets two viral proteins, offering strong protection against Nipah and Hendra viruses while preventing viral escape, potentially contributing to future treatments.

    • Ariel Isaacs
    • Guillermo Valenzuela Nieto
    • Daniel Watterson
    Research
    Nature Structural & Molecular Biology
    Volume: 32, P: 1920-1931

  • During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically control two downstream factors, Ebf1 and Pax5, for modulating this gene rearrangement process.

    • Ashley P. Ng
    • Hannah D. Coughlan
    • Warren S. Alexander
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • SARS-CoV-2 genome sequencing data can be used to infer epidemiological parameters, but the impact of the strategy used to select samples on these estimates is rarely considered. Here, the authors produce estimates using different sampling strategies and compare results to those based on case reporting data.

    • Rhys P. D. Inward
    • Kris V. Parag
    • Nuno R. Faria
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Both extreme weather events and long-term gradual changes drive human migration, which could aggravate the burden of infectious diseases. This Perspective examines the complex interplay between climate change, migration and infectious diseases then advocates for context-specific adaptations.

    • Joseph L.-H. Tsui
    • Rosario Evans Pena
    • Prathyush Sambaturu
    Reviews
    Nature Climate Change
    Volume: 14, P: 793-802

  • Bacterial autotransporters are folded in a process that entraps segments of their N-terminal passenger domain. Here, Leyton et al. identify glycine-aromatic mortise and tenon motifs that mediate the passenger domain’s translocation to the bacterial cell surface, and show that the motifs are evolutionarily conserved.

    • Denisse L. Leyton
    • Matthew D. Johnson
    • Trevor Lithgow
    Research
    Nature Communications
    Volume: 5, P: 1-11

  • Analysis of SARS-CoV-2 genomes from around the world show that following initial importation largely from India, Delta spread in England was driven first by inter-regional travel and then by local population mixing.

    • John T. McCrone
    • Verity Hill
    • Moritz U. G. Kraemer
    ResearchOpen Access
    Nature
    Volume: 610, P: 154-160