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Showing 1–24 of 24 results
Advanced filters: Author: Rhys S Allan Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • During differentiation, chromosome conformation is remodelled to support lineage-specific transcriptional programs. Here, the authors characterise chromosome conformational changes in B lymphocytes as they differentiate into plasma cells, and provide evidence that chromosome reconfiguration occurs prior to DNA replication and mitosis and guides gene expression that controls differentiation.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • MORC2, a chromatin remodeler involved in epigenetic silencing and DNA repair, is linked to cancer and neurological disorders when dysregulated. Here, the authors show that MORC2 binds DNA at multiple sites, clamps onto it, and induces compaction, a process regulated by its phosphorylation.

    • Winnie Tan
    • Jeongveen Park
    • Shabih Shakeel
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Stably silenced genes with methylated CpG at the promoter are refractory to current CRISPR activation systems. Here the authors create a more robust activation system, TETact that recruits DNA-demethylating TET1 with transcriptional activators.

    • Wing Fuk Chan
    • Hannah D. Coughlan
    • Rhys S. Allan
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-9

  • There is increasing evidence that epigenetic mechanisms contribute to therapeutic resistance in cancer. Here the authors study AML patient samples and a mouse model of non-genetic resistance and find that transcriptional plasticity drives stable epigenetic resistance, and identify regulators of enhancer function as important modulators of resistance.

    • Charles C. Bell
    • Katie A. Fennell
    • Mark A. Dawson
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-15

  • RAS, identified over 30 years ago as a potent oncogene, is one of the most commonly mutated genes in cancer. Here the authors show that KR12, an alkylating reagent that specifically cleaves the DNA coding for the G12D and G12V activated variants of KRAS, limits the growth of KRAS mutant cells in vitro and in vivo.

    • Kiriko Hiraoka
    • Takahiro Inoue
    • Hiroki Nagase
    Research
    Nature Communications
    Volume: 6, P: 1-8

  • B cell development is tightly regulated in a stepwise manner to ensure proper generation of repertoire diversity via somatic gene rearrangements. Here, the authors show that a transcription factor, Erg, functions at the earliest stage to critically control two downstream factors, Ebf1 and Pax5, for modulating this gene rearrangement process.

    • Ashley P. Ng
    • Hannah D. Coughlan
    • Warren S. Alexander
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-14

  • The histone modification H3K9me3, the histone methyltransferase SUV39H1 and the H3K9me3-binding protein HP1α participate in maintaining the silent state of the two canonical T helper 1 cell signature genes (which encode interferon-γ and T-bet), ensuring T helper 2 lineage stability in vitro and in vivo; targeting this pathway has the potential to reduce asthma-related pathology.

    • Rhys S. Allan
    • Elina Zueva
    • Sebastian Amigorena
    Research
    Nature
    Volume: 487, P: 249-253

  • Power exhaust is one of the biggest challenges stopping fusion energy. This article shows experimental evidence for strategically shaping the power exhaust region as a solution to this challenge, utilising physics understanding to strike a balance between engineering complexity and power exhaust benefits, consistent with reduced models and simulations.

    • Kevin Verhaegh
    • James Harrison
    • V. Zamkovska
    ResearchOpen Access
    Communications Physics
    Volume: 8, P: 1-15

  • Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.

    • Ricardo Grieshaber-Bouyer
    • Felix A. Radtke
    • Hideyuki Yoshida
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • Helper T cell subsets are characterized functionally by the cytokines they produce. Benoist and colleagues demonstrate that in vivo helper T cells do not manifest as discrete helper subsets but rather form a continuum shaped by microbial exposure.

    • Evgeny Kiner
    • Elijah Willie
    • Hideyuki Yoshida
    Research
    Nature Immunology
    Volume: 22, P: 216-228

  • Zhong et al. exploit allelic variations in mice to pinpoint the ‘heavy lifter’ transcription factor families governing the chromatin landscape of resting and activated T cells.

    • Timothy M. Johanson
    • Rhys S. Allan
    News & Views
    Nature Immunology
    Volume: 23, P: 3-4

  • Some immune cells undergo processes that pose unique challenges to the 3D organization of their genomes. These include antigen receptor rearrangement, clonal expansion and the contortion of their nuclei. Here, Allan and colleagues discuss the latest insights into these processes from a structural genomics perspective.

    • Timothy M. Johanson
    • Wing Fuk Chan
    • Rhys S. Allan
    Reviews
    Nature Reviews Immunology
    Volume: 19, P: 448-456

  • Nature Immunology’s 20th anniversary is a good opportunity to reminisce about the ImmGen collective endeavor — its goals, successes and horror stories — and the group’s exploration of various modes of scientific publishing.

    • Stephanie Vargas Aguilar
    • Oscar Aguilar
    • Caroline Ziemkiewicz
    Comments & Opinion
    Nature Immunology
    Volume: 21, P: 700-703

  • Brown and colleagues generated an atlas of miRNA expression profiles from primary mouse immune cell populations and connected these signatures with ATAC–seq, ChIP–seq and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.

    • Samuel A. Rose
    • Aleksandra Wroblewska
    • Aldrin Yim
    Research
    Nature Immunology
    Volume: 22, P: 914-927