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Showing 1–2 of 2 results
Advanced filters: Author: Riad Seddik Clear advanced filters
  • GABAB receptors are the G-protein-coupled receptors for γ-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain. Here, functional proteomics is used to show that GABAB receptors in the brain are complexes of GABAB1, GABAB2 and members of a subfamily of KCTD proteins. The KCTD proteins increase the potency of agonists and markedly alter the G-protein signalling of the receptors, suggesting that they determine the pharmacology and kinetics of the receptor response.

    • Jochen Schwenk
    • Michaela Metz
    • Bernhard Bettler
    Research
    Nature
    Volume: 465, P: 231-235
  • Morphological and electrophysiological understanding of cerebrospinal fluid-contacting neurons (CSF-cNs) is extended by analysis in the mouse, revealing that they express PKD2L1 and ASICs along with ligand- and voltage-gated channels modulated by metabotropic receptors.

    • Elysa Crozat
    • Edith Blasco
    • Nicolas Wanaverbecq
    ResearchOpen Access
    Communications Biology
    Volume: 8, P: 1-24