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Showing 1–6 of 6 results
Advanced filters: Author: Ricarda Richter-Dennerlein Clear advanced filters

  • Mitochondrial ribosome biogenesis requires the assistance of multiple assembly factors. Here, the authors provide insights into the essential role of the GTPase MTG3 during small subunit biogenesis and a potential coupling to translation initiation.

    • Marleen Heinrichs
    • Anna Franziska Finke
    • Ricarda Richter-Dennerlein
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • Recent findings revealed the extent to which mitochondrial translation and other cellular processes are mutually controlled. Mitochondrial translation is coordinated with the assembly of respiratory chain complexes and is positively regulated by microRNAs imported from the cytoplasm. In turn, mitochondrial translation stress activates retrograde signalling pathways that suppress cell proliferation.

    • Ricarda Richter-Dennerlein
    • Sven Dennerlein
    • Peter Rehling
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 16, P: 586-592

  • Lavdovskaia, Hanitsch, Linden et al. provide a comprehensive roadmap of mitoribosome biogenesis and establish that mitochondria use a unique pathway for the assembly of their translation machinery.

    • Elena Lavdovskaia
    • Elisa Hanitsch
    • Ricarda Richter-Dennerlein
    ResearchOpen Access
    Nature Structural & Molecular Biology
    Volume: 31, P: 1898-1908

  • How translation termination is achieved for the non-conventional mtDNA-encoded COX1 and ND6 was so far unknown. Here, Nadler et al. address this question by assessing the functions and specificity of the mitochondrial release factors mtRF1 and mtRF1a.

    • Franziska Nadler
    • Elena Lavdovskaia
    • Ricarda Richter-Dennerlein
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-10

  • Maturation of the ribosomal peptidyl transferase center (PTC) is mediated by universally conserved GTPases. Here, cryo-EM structures of mitochondrial ribosomal large subunit assembly intermediates and of mature ribosomes offer insight into the roles of several assembly factors, including GTPBP6’s role in both ribosome biogenesis and recycling.

    • Hauke S. Hillen
    • Elena Lavdovskaia
    • Ricarda Richter-Dennerlein
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • RNA modifications are key regulators of RNA functions. Here, the authors identify METTL8 as the enzyme installing m3C32 in mitochondrial tRNAThr/Ser(UCN). Lack of these modifications affects tRNA structure and impairs mitochondrial translation.

    • Nicole Kleiber
    • Nicolas Lemus-Diaz
    • Markus T. Bohnsack
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-19