Nature Search

A safe, T cell-inducing heterologous vaccine against elephant endotheliotropic herpesvirus in a proof-of-concept study

Elephant endotheliotropic herpesvirus (EEHV) haemorrhagic disease is a major threat for juvenile Asian elephants. This study reports a proof-of-concept trial that evaluates the safety and immunogenicity of a vaccine against EEHV.

Tanja Maehr
Javier Lopez
Falko Steinbach
ResearchOpen Access03 Oct 2025
Nature Communications

Volume: 16, P: 1-15
Mycoplasma capping on lymphocytes

Eric J. Stanbridge
Richard L. Weiss
Research07 Dec 1978
Nature

Volume: 276, P: 583-587
Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice

Francisco Pan-Montojo
Oleg Anichtchik
Richard Funk
ResearchOpen Access22 Jun 2009
Nature Precedings

P: 1
Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice

Francisco Pan-Montojo
Oleg Anichtchik
Richard Funk
ResearchOpen Access22 Jun 2009
Nature Precedings

P: 1
Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice

Francisco Pan-Montojo
Oleg Anichtchik
Richard Funk
ResearchOpen Access26 Feb 2010
Nature Precedings

P: 1
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Two doses of the coronavirus disease 2019 vaccine ChAdOx1 nCoV-19 boost antibody responses and functions in phase 1/2 trial participants.

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 279-288
Effects of drugs on the processes regulating the functional activity of brain 5-hydroxytryptamine

A. Richard Green
David G. Grahame-Smith
Research08 Apr 1976
Nature

Volume: 260, P: 487-491
Predicting the course of Gompertzian growth

LARRY NORTON
RICHARD SIMON
ARTHUR E. BOGDEN
Research01 Dec 1976
Nature

Volume: 264, P: 542-545
Author Correction: G-tract RNA removes Polycomb repressive complex 2 from genes

Manuel Beltran
Manuel Tavares
Richard G. Jenner
Amendments and Corrections06 Nov 2019
Nature Structural & Molecular Biology

Volume: 26, P: 1184-1186
Removal of poly(A) and consequent degradation of c-fos mRNA facilitated by 3′ AU-rich sequences

Tim Wilson
Richard Treisman
Research24 Nov 1988
Nature

Volume: 336, P: 396-399
Regeneration of the ventricular myocardium in amphibians

ROBERT O. BECKER
SHARON CHAPIN
RICHARD SHERRY
Research08 Mar 1974
Nature

Volume: 248, P: 145-147
A chimaeric llβ-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension

Richard P. Lifton
Robert G. Dluhy
Jean-Marc Lalouel
Research16 Jan 1992
Nature

Volume: 355, P: 262-265
Basalt derived from highly refractory mantle sources during early Izu-Bonin-Mariana arc development

Magmatism associated with early growth of subduction zones is unlike that of mature island arc systems. Here, the authors find basalts with distinct mineralogical and geochemical characteristics were erupted during this early stage, and derived from extremely refractory, hot mantle sources.

He Li
Richard J. Arculus
Weidong Sun
ResearchOpen Access19 Mar 2021
Nature Communications

Volume: 12, P: 1-10
Monkeypox virus-infected individuals mount comparable humoral immune responses as Smallpox-vaccinated individuals

In this work, Otter et al. compared the humoral immune responses induced by MPXV infection and Smallpox vaccination. Although comparable responses were observed, infection- or vaccination specific serological markers were identified enabling discrimination between vaccinated and infected individuals.

Ashley D. Otter
Scott Jones
Bassam Hallis
ResearchOpen Access23 Sept 2023
Nature Communications

Volume: 14, P: 1-14
The relevance of particle size and zeta-potential in protein processing

W. Richard Bowen
Nicola J. Hall
Paul M. Williams
Special Features01 Aug 1998
Nature Biotechnology

Volume: 16, P: 785-787
Author Correction: Regulatory feedback from nascent RNA to chromatin and transcription

Lenka Skalska
Manuel Beltran-Nebot
Richard G. Jenner
Amendments and Corrections10 Sept 2019
Nature Reviews Molecular Cell Biology

Volume: 20, P: 715
G-tract RNA removes Polycomb repressive complex 2 from genes

PRC2 preferentially binds G tracts within nascent pre-mRNAs, causing transfer of PRC2 from chromatin to RNA upon gene activation, thus providing a mechanism to selectively remove PRC2 from specific genes.

Manuel Beltran
Manuel Tavares
Richard G. Jenner
Research23 Sept 2019
Nature Structural & Molecular Biology

Volume: 26, P: 899-909
Mineral dissolution and reprecipitation mediated by an amorphous phase

Fluid-mediated mineral dissolution is a key mechanism for mineral reactions in the Earth. Here, the authors show that element transport during mineral dissolution and reprecipitation reactions can be mediated by an amorphous phase, which can contain significant amounts of metals.

Matthias Konrad-Schmolke
Ralf Halama
Franziska D. H. Wilke
ResearchOpen Access24 Apr 2018
Nature Communications

Volume: 9, P: 1-9
CTLA-4 expressing innate lymphoid cells modulate mucosal homeostasis in a microbiota dependent manner

At the mucosal interface of the gut and microbiome immune cells play pivotal roles to regulate between commensalism, colonisation and pathogenic invasion. Here, Lo et al. show CTLA-4 expression in innate lymphoid cells is linked to mucosal homeostasis in a microbiome dependent manner.

Jonathan W. Lo
Jan-Hendrik Schroeder
Graham M. Lord
ResearchOpen Access04 Nov 2024
Nature Communications

Volume: 15, P: 1-17
Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA

Biochemical reconstitution of PRC2 interactions with chromatinized templates demonstrates that protein-free linker DNA dominates the PRC2-nucleosome interaction, while RNA inhibits binding.

Xueyin Wang
Richard D Paucek
Thomas R Cech
Research23 Oct 2017
Nature Structural & Molecular Biology

Volume: 24, P: 1028-1038
Local and systemic responses to SARS-CoV-2 infection in children and adults

Mechanisms explaining the milder clinical syndrome that is observed in children with SARS-CoV-2 infection.

Masahiro Yoshida
Kaylee B. Worlock
Kerstin B. Meyer
ResearchOpen Access22 Dec 2021
Nature

Volume: 602, P: 321-327
T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

T-bet and GATA3 regulate differentiation of T cells into Th1 or Th2 cell fates, but little is known about their functional interaction outside of the IFNγ and Il4 /Il5/Il13 loci. Kanhere et al. map these factors across the genome in human T cells, revealing unappreciated breadth of function and interplay between them.

Aditi Kanhere
Arnulf Hertweck
Richard G. Jenner
ResearchOpen Access11 Dec 2012
Nature Communications

Volume: 3, P: 1-12
Regulatory feedback from nascent RNA to chromatin and transcription

Although non-coding RNAs have roles in transcription and chromatin function, nascent pre-mRNA is usually considered to be passive during these processes. Recently identified interactions between nascent pre-mRNAs and regulatory proteins suggest that both types of RNA regulate transcription and chromatin function.

Lenka Skalska
Manuel Beltran-Nebot
Richard G. Jenner
Reviews08 Mar 2017
Nature Reviews Molecular Cell Biology

Volume: 18, P: 331-337
A History of Pediatric Immunology

E Richard Stiehm
Richard B Johnston
Research01 Mar 2005
Pediatric Research

Volume: 57, P: 458-467
Structure of and influence of a tick complement inhibitor on human complement component 5

Complement 5 (C5) generates the C5a anaphylatoxin and C5b, a component of the membrane attack complex. Andersen and colleagues present the crystal structure of C5 and identify similarities and differences between C5 and other complement proteins.

Folmer Fredslund
Nick S Laursen
Gregers R Andersen
Research08 Jun 2008
Nature Immunology

Volume: 9, P: 753-760
Strategy for detection of cancer hazards to man^†

Richard Doll
Reviews17 Feb 1977
Nature

Volume: 265, P: 589-596
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Factors influencing success of clinical genome sequencing across a broad spectrum of disorders

Gilean McVean and colleagues report the results of a large-scale clinical genome sequencing project spanning a broad spectrum of disorders. They identify factors influencing successful genetic diagnosis and highlight the challenges of interpreting findings for genetically heterogeneous disorders.

Jenny C Taylor
Hilary C Martin
Gilean McVean
Research18 May 2015
Nature Genetics

Volume: 47, P: 717-726
Viral infection switches non-plasmacytoid dendritic cells into high interferon producers

Sandra S. Diebold
Maria Montoya
Caetano Reis e Sousa
Research22 Jun 2003
Nature

Volume: 424, P: 324-328
Broad and strong memory CD4⁺ and CD8⁺ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

Questions have arisen as to whether patients with severe COVID-19 disease can generate a T cell response against SARS-CoV-2. Tao Dong and colleagues report that convalescent patients with COVID-19 harbor functional memory CD4⁺ and CD8⁺ T cells that recognize multiple epitopes that span the viral proteome. CD4⁺ T cells predominated the memory response in patients with severe disease, whereas higher proportions of CD8⁺ T cells were found in patients with mild disease.

Yanchun Peng
Alexander J. Mentzer
Tao Dong
Research04 Sept 2020
Nature Immunology

Volume: 21, P: 1336-1345
A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults

Borimas Hanboonkunupakarn
Mavuto Mukaka
Sasithon Pukrittayakamee
ResearchOpen Access06 Jul 2024
npj Vaccines

Volume: 9, P: 1-8
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Identification of host–pathogen-disease relationships using a scalable multiplex serology platform in UK Biobank

Here, the authors design a multiplex serology platform to quantitatively measure antibodies against 20 infectious agents in UK Biobank participants and confirm associations of antibody responses with sociodemographic characteristics, HLA genetic variants, and disease outcomes.

Alexander J. Mentzer
Nicole Brenner
Tim Waterboer
ResearchOpen Access05 Apr 2022
Nature Communications

Volume: 13, P: 1-12
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is efficient in Plasmodiummouse models.

Paul M. O’Neill
Richard K. Amewu
Stephen A. Ward
ResearchOpen Access24 May 2017
Nature Communications

Volume: 8, P: 1-10
Role and species-specific expression of colon T cell homing receptor GPR15 in colitis

The chemoattractant receptor GPR15 can direct CD4⁺ T cells to the colon. Habtezion and colleagues show that GATA-3 and Foxp3 exhibit species-specific differences in promoting GPR15 expression and thereby influences homing of CD4⁺ effector and regulatory T cells.

Linh P Nguyen
Junliang Pan
Aida Habtezion
Research22 Dec 2014
Nature Immunology

Volume: 16, P: 207-213
An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid

Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease.

Vanessa K. Wong
Stephen Baker
Ben Amos
ResearchOpen Access05 Oct 2016
Nature Communications

Volume: 7, P: 1-11
Radioreceptor Binding Profile of the Atypical Antipsychotic Olanzapine

Frank P Bymaster
David O Calligaro
David T Wong
Research01 Feb 1996
Neuropsychopharmacology

Volume: 14, P: 87-96
Insights into host responses against pathogens from transcriptional profiling

Richard G. Jenner
Richard A. Young
Reviews01 Apr 2005
Nature Reviews Microbiology

Volume: 3, P: 281-294
Haemophilus Influenzae Type B Impairment of Pial Vessel Autoregulation in Rats

Ivor D Berkowitz
William R Hayden
M Douglas Jones Jr.
Research01 Jan 1993
Pediatric Research

Volume: 33, P: 48-51
Immune checkpoint modulation enhances HIV-1 antibody induction

Elucidation of broadly neutralizing antibodies (bnAb) is a goal in HIV vaccine development. Here, Bradley et al. show that administration of CTLA-4 blocking antibody with vaccine antigens increases HIV-1 envelope antibody responses in macaques and a bnAb precursor mouse model.

Todd Bradley
Masayuki Kuraoka
Barton F. Haynes
ResearchOpen Access19 Feb 2020
Nature Communications

Volume: 11, P: 1-16
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Production, quality control, stability, and potency of cGMP-produced Plasmodium falciparum RH5.1 protein vaccine expressed in Drosophila S2 cells

Jing Jin
Richard D. Tarrant
Simon J. Draper
ResearchOpen Access17 Aug 2018
npj Vaccines

Volume: 3, P: 1-13
Pan-arthropod analysis reveals somatic piRNAs as an ancestral defence against transposable elements

The widespread presence of somatic PIWI-interacting RNAs targeting transposable elements across the arthropod phylum suggests that this pathway was active in the last common ancestor of arthropods.

Samuel H. Lewis
Kaycee A. Quarles
Francis M. Jiggins
Research04 Dec 2017
Nature Ecology & Evolution

Volume: 2, P: 174-181
A multi-genotype therapeutic human papillomavirus vaccine elicits potent T cell responses to conserved regions of early proteins

Gemma Hancock
Joshua Blight
Lucy Dorrell
ResearchOpen Access10 Dec 2019
Scientific Reports

Volume: 9, P: 1-12
Immunoinformatic identification of B cell and T cell epitopes in the SARS-CoV-2 proteome

Stephen N. Crooke
Inna G. Ovsyannikova
Gregory A. Poland
ResearchOpen Access25 Aug 2020
Scientific Reports

Volume: 10, P: 1-15
Immunomodulatory functions of type I interferons

Type I interferons (IFNs) have become synonymous with antiviral immunity. But, as discussed in this Review, type I IFNs also have roles in bacterial infections, in intestinal homeostasis and in inflammatory and autoimmune diseases.

José M. González-Navajas
Jongdae Lee
Eyal Raz
Reviews06 Jan 2012
Nature Reviews Immunology

Volume: 12, P: 125-135
Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens

No mucosal adjuvant formulation is approved for clinical use, even though boosting immunity at sites of pathogen entry should increase the efficacy of nonreplicating vaccines. Wegmann et al. report that polyethyleneimine (PEI) acts as a potent mucosal adjuvant for protein antigens from influenza and herpes simplex virus, protecting mice against otherwise lethal infections.

Frank Wegmann
Kate H Gartlan
Quentin J Sattentau
Research26 Aug 2012
Nature Biotechnology

Volume: 30, P: 883-888
Effects on National Health dentistry of attempts to control NHS expenditure

Richard Foulsham
Special Features09 Dec 2000
British Dental Journal

Volume: 189, P: 607
Strong immune responses and robust protection following a novel protein in adjuvant tuberculosis vaccine candidate

Marcellus Korompis
Christopher J De Voss
Elena Stylianou
ResearchOpen Access13 Jan 2025
Scientific Reports

Volume: 15, P: 1-18
Chromatin immunoprecipitation and microarray-based analysis of protein location

Tong Ihn Lee
Sarah E Johnstone
Richard A Young
Protocols13 Jul 2006
Nature Protocols

Volume: 1, P: 729-748

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