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Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection

Here authors generate a glycoengineered keratinocyte library delineating human glycosylation pathways. The use of this library reveals that each stage of the HSV-1 infectious cycle is sensitive to alterations in the cellular glycan landscape, identifying critical biosynthetic steps that could be exploited for targeting HSV-1.

Ieva Bagdonaite
Irina N. Marinova
Hans H. Wandall
ResearchOpen Access02 Nov 2023
Nature Communications

Volume: 14, P: 1-19
Epstein–Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

Toni Portis
Richard Longnecker
Research13 Sept 2004
Oncogene

Volume: 23, P: 8619-8628
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

Matthew J. Hart
Alessandra Eva
Richard A. Cerione
Research28 Nov 1991
Nature

Volume: 354, P: 311-314
Fusing structure and function: a structural view of the herpesvirus entry machinery

Entry of enveloped viruses into the host cell is an intricate process. Here, Connolly and colleagues describe the different proteins of herpes simplex viruses and Epstein–Barr virus that are involved in tethering the viruses to host cells and promoting fusion of the viruses with these host cells.

Sarah A. Connolly
Julia O. Jackson
Richard Longnecker
Reviews11 Apr 2011
Nature Reviews Microbiology

Volume: 9, P: 369-381
Human TMEFF1 is a restriction factor for herpes simplex virus in the brain

A study of two childhood cases of herpes simplex encephalitis shows that TMEFF1 interacts with the HSV-1 cell-surface receptor NECTIN-1, preventing HSV-1 from fusing with the cell membrane and entering cortical neurons.

Yi-Hao Chan
Zhiyong Liu
Shen-Ying Zhang
ResearchOpen Access24 Jul 2024
Nature

Volume: 632, P: 390-400
The structural basis of herpesvirus entry

Recent crystallography and electron microscopy studies have refined our model of herpesvirus entry into cells. In this Review, Connolly, Jardetzky and Longnecker discuss recent insights into herpesvirus entry by analysing the structures of entry glycoproteins, including the diverse receptor-binding glycoproteins and conserved fusion proteins.

Sarah A. Connolly
Theodore S. Jardetzky
Richard Longnecker
Reviews21 Oct 2020
Nature Reviews Microbiology

Volume: 19, P: 110-121
Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

The entry of herpesviruses (such as Epstein-Barr virus) into host cells is mediated by a multitude of glycoproteins. Here, the authors show the structure of a viral glycoprotein complex, gHgL/gp42, bound to an anti-gHgL antibody, clarifying determinants of EBV host cell tropism.

Karthik Sathiyamoorthy
Yao Xiong Hu
Theodore S. Jardetzky
ResearchOpen Access08 Dec 2016
Nature Communications

Volume: 7, P: 1-14
Unique functional responses differentially map onto genetic subtypes of dopamine neurons

The authors establish a connection between functional subtypes and genetic subtypes of dopamine neurons in mice and demonstrate that molecular expression patterns can serve as a common framework to dissect dopaminergic functions.

Maite Azcorra
Zachary Gaertner
Daniel A. Dombeck
ResearchOpen Access03 Aug 2023
Nature Neuroscience

Volume: 26, P: 1762-1774
Ephrin receptor A2 is a functional entry receptor for Epstein–Barr virus

The receptor tyrosine kinase EphA2 is identified as an EBV entry and fusion receptor in epithelial cells. EphA2 depletion or absence, or the use of anti-EphA2 antibodies, precludes infection of epithelial cell lines and oropharyngeal carcinoma cells.

Jia Chen
Karthik Sathiyamoorthy
Richard Longnecker
Research01 Jan 2018
Nature Microbiology

Volume: 3, P: 172-180
Circulating adiponectin and leptin and risk of overall and aggressive prostate cancer: a systematic review and meta-analysis

Anya J. Burton
Rebecca Gilbert
Richard M. Martin
ResearchOpen Access11 Jan 2021
Scientific Reports

Volume: 11, P: 1-16
Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following γ-irradiation

Anne E Milner
Roger JA Grand
Christopher D Gregory
Research09 Oct 1997
Oncogene

Volume: 15, P: 1815-1822
Chemical speciation drives hydrothermal vent ecology

George W. Luther III
Tim F. Rozan
S. Craig Cary
Research12 Apr 2001
Nature

Volume: 410, P: 813-816
Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage

Qing Fan
Sarah Kopp
Richard Longnecker
ResearchOpen Access03 Mar 2017
Scientific Reports

Volume: 7, P: 1-12
Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function

Rhoda A. Chang
Stephen D. Miller
Richard Longnecker
ResearchOpen Access03 Apr 2012
Scientific Reports

Volume: 2, P: 1-7
Biomarker and animal models for assessment of retinoid efficacy in cancer chemoprevention

Richard M Niles
Reviews01 Sept 2007
Acta Pharmacologica Sinica

Volume: 28, P: 1383-1391
Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Aurélie Moskal
Heinz Freisling
Nadia Slimani
ResearchOpen Access20 Oct 2016
British Journal of Cancer

Volume: 115, P: 1430-1440
Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials

X Zhang
C Liu
Y Song
Research20 May 2015
European Journal of Clinical Nutrition

Volume: 70, P: 162-169
Unravelling mechanisms of p53-mediated tumour suppression

There are many cellular outcomes attributable to p53 activation, but identifying which of these, or which combination of these, is important for tumour suppression has remained challenging. As new roles for p53 emerge, this Opinion dissects the role of p53 in tumour suppression.

Kathryn T. Bieging
Stephano Spano Mello
Laura D. Attardi
Reviews17 Apr 2014
Nature Reviews Cancer

Volume: 14, P: 359-370

Search

Glycoengineered keratinocyte library reveals essential functions of specific glycans for all stages of HSV-1 infection

Epstein–Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbloncogene product

Fusing structure and function: a structural view of the herpesvirus entry machinery

Human TMEFF1 is a restriction factor for herpes simplex virus in the brain

The structural basis of herpesvirus entry

Structural basis for Epstein–Barr virus host cell tropism mediated by gp42 and gHgL entry glycoproteins

Unique functional responses differentially map onto genetic subtypes of dopamine neurons

Ephrin receptor A2 is a functional entry receptor for Epstein–Barr virus

Circulating adiponectin and leptin and risk of overall and aggressive prostate cancer: a systematic review and meta-analysis

Differential effects of BCL-2 on survival and proliferation of human B-lymphoma cells following γ-irradiation

Chemical speciation drives hydrothermal vent ecology

Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage

Epstein-Barr virus latent membrane protein 2A exacerbates experimental autoimmune encephalomyelitis and enhances antigen presentation function

Biomarker and animal models for assessment of retinoid efficacy in cancer chemoprevention

Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Selenium status and cardiovascular diseases: meta-analysis of prospective observational studies and randomized controlled trials

Unravelling mechanisms of p53-mediated tumour suppression

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