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The functional organization of the posterior parietal cortex (PPC) for guiding eye movements has remained unknown. Here, the authors use functional ultrasound neuroimaging to reveal small, tuned clusters in PPC that reliably encode where we look over months to years.

Since joining Imperial College as rector in January 2001, former GlaxoSmithKline chairman Richard Sykes has been calling for better stipends for graduate students and postdocs, and more money in general for UK science. During the recent Biotechnology Industry Organization (BIO) meeting in San Francisco, he took a few minutes with Naturejobs editor Paul Smaglik to discuss scientific career paths, the shifting demographics of scientific employment and how academia can do a better job of preparing scientists to work with industry - whatever sector they stay in. This conversation has been lightly edited for brevity and clarity.

In the randomized phase 1b/2 Morpheus-Melanoma trial evaluating various neoadjuvant immune checkpoint inhibitor regimens in patients with resectable stage III melanoma, tobemstomig, an anti-PD-1/anti-LAG-3 bispecific antibody, showed the highest pathologic response rate with a better safety profile than the standard treatment approach of ipilimumab plus nivolumab.

The authors show that nonlinear self-confinement of magnons in a thick iron garnet film enables magnetic auto-oscillations via local electrical spin injection, resulting in mode-dependent and directional magnon emission in extended magnetic layers.

Homojunction intermolecular charge separation is reported in photoexcited anion–cation pairs induced by external electric field bias, opening possibilities for light harvesting using molecular semiconductors.

Human papillomavirus (HPV)-associated oropharyngeal cancer is increasing but the natural history of oral HPV infection is not well understood. Here, the authors investigate clearance of oncogenic oral HPV infection in a cohort of men from the US, Brazil, and Mexico.

In a prospective study enrolling 1,222 patients from 22 emergency departments, a device using a machine-learning-based signature of blood mRNAs demonstrated clinically acceptable performance to diagnose bacterial and viral infections and to predict the all-cause need for critical care interventions within 7 days, with benchmark to established biomarkers and risk scores.

The authors identify thousands of genetic variants affecting RNA splicing in primary human chondrocytes and link several of them to osteoarthritis risk using genome editing and computational approaches.

In a randomized trial of patients with a previous myocardial infarction and with residual inflammation, a monoclonal antibody targeting the LOX-1 receptor, thought to contribute to atherosclerotic plaque progression and inflammation, reduced soluble LOX-1 and interleukin-6 levels but did not lead to a substantial reduction in coronary plaque volume.

As presented at the 2025 ASCO Annual Meeting: in cohort 3 of the phase 2 TUXEDO-3 trial, patients with leptomeningeal metastatic disease from any solid tumor were treated with the HER3-targeting antibody–drug conjugate patritumab deruxtecan and showed encouraging 3-month overall survival rates.

While many genetic loci have been found to be associated with disease, not many have had their causal variants and mechanisms investigated. Here, the authors experimentally dissect two loci near GDF5 which are associated with two different joint disorders and which map to independent regulatory elements.

Diorganozinc reagents (ZnR₂, e.g. R = Et, Ph, C₆F₅) are widely used as Lewis acid catalysts or Lewis base reagents, however, descriptors for predicting the influence of the R substituent are scarce. Here, by using liquid-phase X-ray spectroscopy, the authors have identified the geometric structures of diorganozincs in weakly coordinating solvents and then established Zn-specific descriptors to quantify the properties of their underlying Lewis acidity/basicity.

Semiconductor quantum dots that simultaneously support blue and yellow emission offer a route to realizing efficient white light-emitting diodes.

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

This study identifies an electrically anisotropic layer within the lithospheric mantle of the Superior Craton, interpreted as a network of preferentially oriented phlogopite-bearing domains emplaced as a result of Proterozoic geodynamic activity.

This study reveals that Holocene drying-induced woody plant expansion in peatlands suppresses microbial heterotrophic activity and enhances organic matter stability, creating a natural buffer for carbon storage under climatic stress.

Structural analyses of antibody-virus complexes offer critical insights into immune recognition mechanisms. In this report, we present how a patient-derived IgG recognizes a quaternary epitope on EEEV particles through strictly bivalent interactions.

The spontaneous breaking of chiral symmetry in ferroelectric nematic systems has opened new avenues for exploring exotic textures in liquid crystalline ferromagnets. Authors reveal that the polar smectic phase coexisting with a chiral ferroelectric nematic is itself helical, exhibits pseudo-ferrielectric switching, and shows both first- and second-order helix formation, with pre-transitional helices emerging in the nematic phase.

NIPBL perturbation activates long terminal repeat (LTR)-derived alternative promoters due to reorganization of chromatin’s hierarchical structure, leading to LTR co-option and oncogene activation in melanoma cell lines.

The interglacial period that occurred about 400,000 years ago—Marine Isotope Stage 11—was the longest out of the past five glacial cycles. A proxy-based alignment of this interglacial with the Holocene, and a subsequent analysis of carbon isotopic data from marine sediments, indicates that the unusual length may have been driven by strong poleward oceanic heat transport.

A high-bandwidth neuromotor interface offers performant out-of-the-box generalization across people.

Carbon nanotube mechanical resonators are difficult to couple optomechanically to microwave fields. Here, the authors exploit Coulomb blockade’s nonlinearity to amplify the single photon coupling between a suspended carbon nanotube quantum dot and a microwave cavity by several orders of magnitude.

Demonstration of ballistic conduction and spin polarization of edge state currents in two dimensional topological insulators remains a challenge. Here, Muraniet al. report a direct signature of ballistic one dimensional transport along the topological surfaces of a bismuth nanowire connected to superconducting electrodes.

Group-IV color centers in diamond show promise for spin-photon interfaces, but precise positioning and activation are challenging. Here the authors combine site-controlled ion implantation with laser annealing and in-situ photoluminescence monitoring to create and tune individual tin vacancy centers in diamond.

Quasi-elastic neutron scattering measurements show the existence of a body-centred cubic structure, similar to that of ice VII, where water molecules exhibit picosecond rotational dynamic and rapid orientational jumps characteristic of liquid water.

Observations from a borehole in the Kamb Ice Stream suggest that discrete subglacial discharge events dominate channel melt and sediment transport.

Comprehensively understanding the ultrafast dynamics of the insulator-to-metal transition in vanadium dioxide is a long-standing challenge. Here, the authors measure the electronic and structural phase transitions in the first hundred femtoseconds.

Non-uniform noise introduces bias in multivariate analysis of mass spectrometry data. Here, the authors study the noise structure of the widely used Orbitrap to develop a data scaling method that reduces this bias resulting in clearer separation of chemical information from noise in biological data.

Coelacanths are known for their conservative morphology. Here, the authors describe a 380 million year-old coelacanth fossil from the Gogo Formation (Western Australia) with morphology representative of a key transition where coelacanth morphology disparity shifts.

A gold catalyst supported on intergrown titanosilicate zeolites enhances propene oxide production by activating oxygen-transfer intermediates more efficiently at Ti interface sites.