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“In subarachnoid hemorrhage (SAH), therapies are limited and clinical outcomes remain disappointing. The authors show a contribution of the urotensin II system in microvascular changes, vasospasm, neuroinflammation and cognitive deficits post-SAH, primarily through meningeal cells and border-associated macrophages

The introduction of mandatory calorie labelling in out-of-home food outlets in England was not associated with a reduction in calories purchased or consumed. There was a post-policy increase in self-reported noticing and use of calorie labelling.

Neuromorphic software and hardware solutions vary widely, challenging interoperability and reproducibility. Here, authors establish a representation for neuromorphic computations in continuous time and demonstrate support across 11 platforms.

Developed using diverse sources of histopathology images, biomedical text and over 1.17 million image–caption pairs, evaluated on a suite of 14 diverse benchmarks, a visual-language foundation model achieves state-of-the-art performance on a wide array of clinically relevant pathology tasks.

Obesity and cancer-induced cachexia are linked to an impairment in the ability of muscle to use glucose or lipids interchangeably as energy substrates. Here, the authors propose that Drosophila REPTOR and its mammalian ortholog CREBRF act as key transcriptional regulators of fuel choice in muscle.

Parathyroid glands are crucial for balancing blood calcium levels. Here, the authors generate comprehensive maps of the chromatin landscape of human parathyroids, linking identified regulatory elements to key functions in calcium homeostasis.

In the phase 2 RENOBATE trial, the combination of regorafenib and nivolumab as first-line treatment for unresectable hepatocellular carcinoma exhibited a safe profile and met the primary endpoint with a 31% overall response rate.

Antarctic ice core records provide insights into past environmental conditions. Here, an abrupt, synchronous increase in dust from ice cores in Antarctica is identified that suggests a sudden equatorward shift of westerly winds and coincides with a reduction in atmospheric CO2.

Genome-wide association studies of individuals from an isolated population (data from the Finnish biobank study FinnGen) and consequent meta-analyses facilitate the identification of previously unknown coding variant associations for both rare and common diseases.

Semiconducting armchair graphene nanoribbons with sub-10 nm width are of great technological importance but yet to realize. Here, the authors report growth of such nanoribbons on germanium and controlled crystallographic orientation and well-defined armchair edges are obtained.

It is generally accepted that Polynesian settlers were directly responsible for the extinction of New Zealand moa. Here, the authors present three series of radiocarbon ages that define the brief period of interaction between Polynesians and moa, and show that high human population densities are not a prerequisite for the extinction of megafauna populations.

Mass spectrometry (MS)-based protein sequencing usually relies on in-solution proteolytic digestion, which is time-consuming and inefficient for certain proteins. Here, the authors achieve full protein sequence coverage in less than 1 ms by subjecting protein-protease mixtures to electrosonic spray ionization-MS.

The β₁-adrenergic receptor (β₁AR) is a G-protein-coupled receptor (GPCRs) that binds catecholamine ligands. Here the authors employ site-specific labelling and ¹⁹F NMR measurements to characterise the structural changes and dynamics in the cytoplasmic region of β₁AR upon agonist stimulation and coupling to a G_s-protein-mimetic nanobody.

Pumas are experiencing increased isolation as human persecution and habitat loss fragment the populations of this once widespread species. Here, the authors estimate the genomic consequences of this isolation by analyzing the genomes of ten pumas from across North and South America.

A multi-ancestry genome-wide association meta-analysis of kidney cancer identifies 63 regions associated with disease susceptibility including one locus that was associated with increased risk in individuals with African ancestry.

Owing to its driven-dissipative nature, and its solid-state environment, a resonantly driven polariton condensate can be accompanied by an incoherent reservoir of excitons. Stepanov et al. demonstrate that this situation strongly modifies the spectrum of collective excitations, which determines many quantum hydrodynamic features in a polariton fluid.

Resonant driving of a nanoscale quantum system coupled to a microscopic mechanical resonator may have uses in precision sensing and quantum information. The authors realize this by tailoring the geometry of a semiconductor nanowire embedding a quantum dot, detecting sub-picometre displacements.

Mantle flow can warp Earth’s surface. Reconstructions of surface deformation in Angola over the past 45,000 years reveal rapid uplift of about 2 mm per year, implying that mantle-induced uplift may occur in quick pulses.

An endogenous proteasome inhibitor was identified 30 years ago, but its mechanism remained unclear. Rawson et al. show that this inhibitor is present within the interior of the proteasome, where it simultaneously inhibits all six active sites.

Liu et al. report structures of human sphingosine 1-phosphate (S1P) receptor 1 (S1P₁) in complex with Gi and S1P or the multiple sclerosis (MS) drug Siponimod, as well as human lysophosphatidic acid (LPA) receptor 1 (LPA₁) in complex with Gi and LPA, revealing distinct conformations of the lysophospholipids interacting with their cognate GPCRs.

Current understanding of Long COVID is limited, in part, due to lack of evidence from population-representative studies. Here, the authors analyse data from ten UK population-based studies and electronic health records, and find wide variation in the frequency of Long COVID between studies but some consistent risk factors.

Genome-wide analyses identify variants associated with sinus node dysfunction, distal conduction disease and pacemaker implantation, implicating ion channel function, cardiac developmental programs and sarcomeric structure in bradyarrhythmia susceptibility.

Understanding the physical origin on hysteresis in organic electrochemical transistors is important for achieving non-volatility. Here, the authors report a thermodynamic framework that explains the emergence of bistable device operation via the interplay of enthalpy and entropy.

A computational study identifies pressure-induced reactivity between the two lightest metals, lithium and beryllium. Although normally not even miscible, they form a number of ordered alloy compounds stable at high pressures. Intriguingly, quasi-two-dimensional electronic states emerge within the three-dimensional crystal environment of one of the alloys. This feature appears as the high pressure 'squeezes' electrons away from the lithium atoms and into layers of almost ideal free-electron like states that are close to the beryllium atoms.

The first known phosphorus-rich deposits formed 2 billion years ago, but their origins are unclear. Geochemical and palaeontological analyses of 2-billion-year-old deposits from northwest Russia suggest that the presence of sulphur-oxidizing bacteria and a sharp oxic–anoxic transition in the sediments allowed for phosphorus accumulation in this setting.

In this non-comparative trial, patients with BRAF^V600-mutant resectable melanoma received either pembrolizumab alone, a sequential combination of pembrolizumab, dabrafenib and trametinib, or a concurrent combination thereof, showing encouraging clinical response rates in the concurrent therapy arm and awaiting longer follow-up.

During the 2022 Hunga Volcano eruption, 10 km³ of seafloor material was removed, fueling long-run out seafloor density currents. These powerful currents damaged seafloor cables over a length of >100 km, reshaped the seafloor, and caused mass-mortality of seafloor life.

The returned samples from Hayabusa2 show that C-type asteroid Ryugu experienced various steps of mineralogical alteration within only 1–2 million years after accretion.

Why β-amyloid plaque initially accumulates in the default mode network of the cortex before Alzheimer’s disease diagnosis is not known. Here, the authors show that this accumulation is associated with a reduction of global brain activity in these regions.

The study reveals limitations in widely used RNA-seq aligners, which create 'phantom' introns in reference databases. The authors introduce EASTR, a computational tool that not only enhances alignment accuracy but also uncovers existing annotation errors. This improvement bolsters the dependability of subsequent RNA-seq analyses.

Surface strain can be used in gas phase catalysis and electrocatalysis to control the binding energies of adsorbates on active sites, but in situ or operando strain measurements can be challenging. Coherent diffraction now allows strain inside individual Pt nanoparticles to be mapped and quantified under electrochemical control.