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Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen

Pathogen-associated molecular patterns are involved in the initiation of anti-pathogen immunity but their importance for sustaining this response is not established. Here, the authors show that persistent presence of pathogen-associated molecular patterns is required to maintain robust immune responses to pathogens.

Samarchith P. Kurup
Rick L. Tarleton
Research23 Oct 2013
Nature Communications

Volume: 4, P: 1-10
Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

A newly discovered benzoxaborole prodrug AN15368 cures Trypanosoma cruzi infection (the cause of Chagas disease) in mice and in naturally infected non-human primates.

Angel M. Padilla
Wei Wang
Rick L. Tarleton
ResearchOpen Access05 Sept 2022
Nature Microbiology

Volume: 7, P: 1536-1546
Drug-induced cure drives conversion to a stable and protective CD8⁺ T central memory response in chronic Chagas disease

Juan M Bustamante
Lisa M Bixby
Rick L Tarleton
Research20 Apr 2008
Nature Medicine

Volume: 14, P: 542-550
Protozoan persister-like cells and drug treatment failure

Protozoa use various mechanisms to establish persistent infections. In this Review, Barrett and colleagues describe protozoan parasite ‘persister-like cells’, and they explore their possible role in persistent infections and drug treatment failure, and outline possible treatment options.

Michael P. Barrett
Dennis E. Kyle
Rick L. Tarleton
Reviews23 Aug 2019
Nature Reviews Microbiology

Volume: 17, P: 607-620
Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

Andrés Sanchez Alberti
Augusto E. Bivona
Emilio L. Malchiodi
ResearchOpen Access10 Apr 2017
npj Vaccines

Volume: 2, P: 1-12

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Perpetual expression of PAMPs necessary for optimal immune control and clearance of a persistent pathogen

Discovery of an orally active benzoxaborole prodrug effective in the treatment of Chagas disease in non-human primates

Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease

Protozoan persister-like cells and drug treatment failure

Engineered trivalent immunogen adjuvanted with a STING agonist confers protection against Trypanosoma cruzi infection

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Drug-induced cure drives conversion to a stable and protective CD8⁺ T central memory response in chronic Chagas disease