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Showing 101–150 of 177 results

Advanced filters: Author: Rick M. Thomas Clear advanced filters

Deep brain stimulation for obsessive–compulsive disorder: a crisis of access

Deep brain stimulation is an effective treatment for obsessive–compulsive disorder but is rarely used. Action is needed by psychologists, psychiatrists and insurers so that patients with otherwise intractable cases can receive this therapy to improve their mental health.

Veerle Visser-Vandewalle
Pablo Andrade
Michael S. Okun
Comments & Opinion15 Jul 2022
Nature Medicine

Volume: 28, P: 1529-1532
Chinese scientists and US leadership in the life sciences

Steven H. Holtzman
Ron Cohen
Shuguang Zhang
Correspondence03 Oct 2019
Nature Biotechnology

Volume: 37, P: 1261-1263
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer

Rosalind Eeles, Christopher Haiman and colleagues report genome-wide association and meta-analyses of prostate cancer in populations of European, African, Japanese and Latino ancestry. They identify 23 new susceptibility loci, including one associated with early-onset prostate cancer.

Ali Amin Al Olama
Zsofia Kote-Jarai
Christopher A Haiman
Research14 Sept 2014
Nature Genetics

Volume: 46, P: 1103-1109
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21

Christopher Haiman and colleagues report a genome-wide association study for prostate cancer in African-American males drawn from 11 epidemiological studies of prostate cancer, with replication including individuals of African ancestry from 10 additional studies worldwide. They identify a new susceptibility locus on chromosome 17q21, for which the risk allele shows a higher frequency in men of African ancestry than in other populations. This may explain some of the increased incidence of prostate cancer in men of African ancestry.

Christopher A Haiman
Gary K Chen
Brian E Henderson
Research22 May 2011
Nature Genetics

Volume: 43, P: 570-573
Malaria-protective traits at odds in Africa?

Sickle hemoglobin and α-thalassemia evolved as two of the most common human genetic polymorphisms because they confer protection against malaria. New evidence suggests that their effects may interfere with each other, raising questions about these hemoglobinopathies and their mechanisms of protection.

Thomas E Wellems
Rick M Fairhurst
News & Views01 Nov 2005
Nature Genetics

Volume: 37, P: 1160-1162
Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Azmeraw T. Amare
Klaus Oliver Schubert
Bernhard T. Baune
Research16 Mar 2020
Molecular Psychiatry

Volume: 26, P: 2457-2470
Author Correction: Common and rare variant association analyses in amyotrophic lateral sclerosis identify 15 risk loci with distinct genetic architectures and neuron-specific biology

Wouter van Rheenen
Rick A. A. van der Spek
Jan H. Veldink
Amendments and CorrectionsOpen Access31 Jan 2022
Nature Genetics

Volume: 54, P: 361
Relevance of the international spinal cord injury basic data sets to youth: an Inter-Professional review with recommendations

A Carroll
L C Vogel
M J Mulcahey
Research28 Feb 2017
Spinal Cord

Volume: 55, P: 875-881
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections22 May 2024
Nature Medicine

Volume: 30, P: 2091
Human Proteinpedia enables sharing of human protein data

Suresh Mathivanan
Mukhtar Ahmed
Akhilesh Pandey
Correspondence01 Feb 2008
Nature Biotechnology

Volume: 26, P: 164-167
Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human Schwannoma cells

Patricia D Pelton
Larry S Sherman
Nancy Ratner
Research29 Oct 1998
Oncogene

Volume: 17, P: 2195-2209
Radical prostatectomy — aftercare should not be an afterthought

Focus on quality of life after prostate cancer is vital to improve patient care. Improved assessment and proactive management of post-treatment functional outcomes is essential. Many aspects of the patients’ aftercare need to be improved in order to set up a clear path following prostatectomy. These improvements will enable a timely and efficient escalation of treatment and ameliorate patients’ survivorship experience.

Findlay MacAskill
Arun Sahai
Sachin Malde
Comments & Opinion01 Oct 2021
Nature Reviews Urology

Volume: 18, P: 703-704
Allocation and validation of the second revision of the International Staging System in the ICARIA-MM and IKEMA studies

Paul G. Richardson
Aurore Perrot
Philippe Moreau
ResearchOpen Access28 Nov 2024
Blood Cancer Journal

Volume: 14, P: 1-11
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

Evangelos Evangelou
Helen R. Warren
Mark J. Caulfield
Amendments and Corrections14 Nov 2018
Nature Genetics

Volume: 50, P: 1755
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections14 Nov 2023
Nature Medicine

Volume: 30, P: 603
Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Amendments and Corrections13 Dec 2023
Nature Medicine

Volume: 30, P: 605
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank

Jonathan R. I. Coleman
Wouter J. Peyrot
Gerome Breen
Research23 Jan 2020
Molecular Psychiatry

Volume: 25, P: 1430-1446
Cell adhesion: integrating cytoskeletal dynamics and cellular tension

Cell migration affects all morphogenetic processes and contributes to numerous diseases, including cancer and cardiovascular disease. Adhesion formation and disassembly drive the migration cycle by activating Rho GTPases, which in turn regulate actin polymerization and myosin II activity, and therefore adhesion dynamics.

J. Thomas Parsons
Alan Rick Horwitz
Martin A. Schwartz
Reviews01 Sept 2010
Nature Reviews Molecular Cell Biology

Volume: 11, P: 633-643
Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk

Richard Houlston and colleagues report a genome-wide association study for colorectal cancer. They report three loci newly associated with colorectal cancer, bringing the total number of common susceptibility loci to 20.

Malcolm G Dunlop
Sara E Dobbins
Richard S Houlston
Research27 May 2012
Nature Genetics

Volume: 44, P: 770-776
A joint international consensus statement for measuring quality of survival for patients with childhood cancer

The International Childhood Cancer Outcome Project group, involving survivors and other relevant stakeholders, develop a set of core outcomes to measure the quality of care for 17 types of childhood cancers.

Rebecca J. van Kalsbeek
Melissa M. Hudson
Lisa Zwiers
Reviews15 Jun 2023
Nature Medicine

Volume: 29, P: 1340-1348
Spinal ganglion cyst presenting with radiculopathy: diagnostic challenges and differential

Lohit Velagapudi
Caio M. Matias
James S. Harrop
Research19 Jan 2021
Spinal Cord Series and Cases

Volume: 7, P: 1-4
International Spinal Cord Injury Spinal Column Injury Basic Data Set

M F Dvorak
P C Wing
V K Noonan
Research05 Jun 2012
Spinal Cord

Volume: 50, P: 817-821
International Spinal Cord Injury: Spinal Interventions and Surgical Procedures Basic Data Set

M F Dvorak
E Itshayek
V K Noonan
Research25 Nov 2014
Spinal Cord

Volume: 53, P: 155-165
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability

Vasiliki Lagou
Reedik Mägi
Inga Prokopenko
Amendments and CorrectionsOpen Access08 Feb 2021
Nature Communications

Volume: 12, P: 1-2
Genetic and phenotypic characterization of Parkinson’s disease at the clinic-wide level

Thomas F. Tropea
Whitney Hartstone
Alice S. Chen-Plotkin
ResearchOpen Access03 May 2024
npj Parkinson's Disease

Volume: 10, P: 1-8
AI-accelerated protein-ligand docking for SARS-CoV-2 is 100-fold faster with no significant change in detection

Austin Clyde
Xuefeng Liu
Rick Stevens
ResearchOpen Access06 Feb 2023
Scientific Reports

Volume: 13, P: 1-14
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders

Till F. M. Andlauer
Jose Guzman-Parra
Marcella Rietschel
ResearchOpen Access11 Nov 2019
Molecular Psychiatry

Volume: 26, P: 1286-1298
Common data elements for spinal cord injury clinical research: a National Institute for Neurological Disorders and Stroke project

F Biering-Sørensen
S Alai
L B Jakeman
Reviews10 Feb 2015
Spinal Cord

Volume: 53, P: 265-277
Decorin prevents metastatic spreading of breast cancer

Charles C Reed
Anna Waterhouse
Renato V Iozzo
Research27 Dec 2004
Oncogene

Volume: 24, P: 1104-1110
The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli
Massimo Bogliolo
Paolo Peterlongo
ResearchOpen Access01 Nov 2019
npj Breast Cancer

Volume: 5, P: 1-14
Organic carbon burial in Mediterranean sapropels intensified during Green Sahara Periods since 3.2 Myr ago

Mediterranean sediment records spanning the last five million years suggest an abrupt increase in carbon burial and terrigenous accumulation coincided with enhanced fluvial sediment mobilisation in North Africa during orbitally-driven Green Sahara Periods.

Katharine M. Grant
Udara Amarathunga
Eelco J. Rohling
ResearchOpen Access13 Jan 2022
Communications Earth & Environment

Volume: 3, P: 1-9
Large libraries of single-chain trimer peptide-MHCs enable antigen-specific CD8+ T cell discovery and analysis

A high-throughput platform enables the production of single-chain trimers for any pairing of peptide and Class I HLA allele for rapid discovery of epitopes and capture of antigen-specific CD8 + T cells for functional characterization.

William Chour
Jongchan Choi
James R. Heath
ResearchOpen Access16 May 2023
Communications Biology

Volume: 6, P: 1-13
Heterodera glycines utilizes promiscuous spliced leaders and demonstrates a unique preference for a species-specific spliced leader over C. elegans SL1

Stacey N. Barnes
Rick E. Masonbrink
Thomas J. Baum
ResearchOpen Access04 Feb 2019
Scientific Reports

Volume: 9, P: 1-11
A framework for community and ecosystem genetics: from genes to ecosystems

Genotypes act not only on individuals but on entire ecological communities. Although it is a complex undertaking, it is possible to extend population and quantitative genetics principles to understanding ecosystem processes, and place them in an evolutionary framework.

Thomas G. Whitham
Joseph K. Bailey
Stuart C. Wooley
Reviews01 Jul 2006
Nature Reviews Genetics

Volume: 7, P: 510-523
Introducing a Bayesian model of selective attention based on active inference

M. Berk Mirza
Rick A. Adams
Thomas Parr
ResearchOpen Access26 Sept 2019
Scientific Reports

Volume: 9, P: 1-22
Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array

Edward J Saunders
Tokhir Dadaev
Zsofia Kote-Jarai
ResearchOpen Access10 Mar 2016
British Journal of Cancer

Volume: 114, P: 945-952
A resource of targeted mutant mouse lines for 5,061 genes

The International Mouse Phenotyping Consortium reports the generation of new mouse mutant strains for more than 5,000 genes, including 2,850 novel null, 2,987 novel conditional-ready and 4,433 novel reporter alleles.

Marie-Christine Birling
Atsushi Yoshiki
Stephen A. Murray
Comments & Opinion08 Apr 2021
Nature Genetics

Volume: 53, P: 416-419
A global biophysical typology of mangroves and its relevance for ecosystem structure and deforestation

Thomas A. Worthington
Philine S. E. zu Ermgassen
Mark Spalding
ResearchOpen Access04 Sept 2020
Scientific Reports

Volume: 10, P: 1-11
First-line sequential high-dose VIP chemotherapy with autologous transplantation for patients with primary mediastinal nonseminomatous germ cell tumours: a prospective trial

C Bokemeyer
N Schleucher
J T Hartmann
ResearchOpen Access01 Jul 2003
British Journal of Cancer

Volume: 89, P: 29-35
Multi-omic single cell analysis resolves novel stromal cell populations in healthy and diseased human tendon

Adrian R. Kendal
Thomas Layton
Andrew Carr
ResearchOpen Access03 Sept 2020
Scientific Reports

Volume: 10, P: 1-14
Antimicrobial Resistance Prediction in PATRIC and RAST

James J. Davis
Sébastien Boisvert
Rick Stevens
ResearchOpen Access14 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
Biodiversity estimates and ecological interpretations of meiofaunal communities are biased by the taxonomic approach

Francesca Leasi et al. report a comparison of approaches for estimating meiofauna diversity, including metabarcoding and other morphological-based taxonomy methods. They show bias in estimates based on methods and phyla, highlighting the need for a standard procedure for assessing biodiversity.

Francesca Leasi
Joseph L. Sevigny
W. Kelley Thomas
ResearchOpen Access14 Aug 2018
Communications Biology

Volume: 1, P: 1-12
AKT/mTOR signaling modulates resistance to endocrine therapy and CDK4/6 inhibition in metastatic breast cancers

Maysa M. Abu-Khalaf
K. Alex Hodge
Mariaelena Pierobon
ResearchOpen Access16 Feb 2023
npj Precision Oncology

Volume: 7, P: 1-12
A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies

Darren C. Phillips
Sha Jin
Andrew J. Souers
ResearchOpen Access11 Dec 2019
Leukemia

Volume: 34, P: 1646-1657
Structural variation analysis of 6,500 whole genome sequences in amyotrophic lateral sclerosis

Ahmad Al Khleifat
Alfredo Iacoangeli
Ammar Al-Chalabi
ResearchOpen Access28 Jan 2022
npj Genomic Medicine

Volume: 7, P: 1-8
De novo transcript sequence reconstruction from RNA-seq using the Trinity platform for reference generation and analysis

Brian J Haas
Alexie Papanicolaou
Aviv Regev
Protocols11 Jul 2013
Nature Protocols

Volume: 8, P: 1494-1512
Developing an in silico minimum inhibitory concentration panel test for Klebsiella pneumoniae

Marcus Nguyen
Thomas Brettin
James J. Davis
ResearchOpen Access11 Jan 2018
Scientific Reports

Volume: 8, P: 1-11
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorder

Simone de Jong et al. examine the balance of common and rare risk for psychiatric disorders in a large family with high incidence of Bipolar Disorder and Major Depressive Disorder. They find that increased polygenic risk over generations could be partially due to assortative mating, which may explain the observation of anticipation in mood disorders.

Simone de Jong
Mateus Jose Abdalla Diniz
Gerome Breen
ResearchOpen Access08 Oct 2018
Communications Biology

Volume: 1, P: 1-10
Converting tabular data into images for deep learning with convolutional neural networks

Yitan Zhu
Thomas Brettin
Rick L. Stevens
ResearchOpen Access31 May 2021
Scientific Reports

Volume: 11, P: 1-11
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System Genes

Liz Rietschel
Fabian Streit
Marcella Rietschel
ResearchOpen Access10 Nov 2017
Scientific Reports

Volume: 7, P: 1-15

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