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Showing 1–25 of 25 results
Advanced filters: Author: Ricky A. Sharma Clear advanced filters

  • Federated learning (FL) algorithms have emerged as a promising solution to train models for healthcare imaging across institutions while preserving privacy. Here, the authors describe the Federated Tumor Segmentation (FeTS) challenge for the decentralised benchmarking of FL algorithms and evaluation of Healthcare AI algorithm generalizability in real-world cancer imaging datasets.

    • Maximilian Zenk
    • Ujjwal Baid
    • Spyridon Bakas
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-20

  • Oesophageal adenocarcinoma is often treated with chemotherapy before surgery. Here, the authors sequence cancer samples before and after chemotherapy and examine how the genome changes, focusing on changes in driver gene mutations and differential clonal evolution between good and poor responders.

    • John M. Findlay
    • Francesc Castro-Giner
    • Ian Tomlinson
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13

  • Federated ML (FL) provides an alternative to train accurate and generalizable ML models, by only sharing numerical model updates. Here, the authors present the largest FL study to-date to generate an automatic tumor boundary detector for glioblastoma.

    • Sarthak Pati
    • Ujjwal Baid
    • Spyridon Bakas
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • The National Cancer Research Institute Clinical and Translational Radiotherapy Research Working Group (CTRad) includes academia, industry, patient groups and regulatory bodies representatives. In this Consensus Statement, recommendations are provided with the aim of increasing the number of novel drugs being successfully registered in combination with radiotherapy in clinical trials for patients with cancer.

    • Ricky A. Sharma
    • Ruth Plummer
    • Stephen R. Wedge
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 13, P: 627-642

  • A multidisciplinary approach is essential for the optimization of patient care in oncology, especially in the current landscape, in which standard-of-care approaches to cancer treatment are evolving towards highly targeted treatments, precise image guidance and personalized cancer therapy. Herein, the authors discuss current career development pathways for oncologists, suggesting strategies to improve clinical training and research, with specific emphasis on the involvement of trainees in multidisciplinary teams.

    • Alison C. Tree
    • Victoria Harding
    • Ricky A. Sharma
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 14, P: 508-517

  • Radio-embolization using radioactive microspheres allows the delivery of high-dose internal radiotherapy to malignant tumors of the liver. The surrogate for measuring flow dynamics for radio-embolization planning does not best represent treatment efficacy. Therefore, Morgan et al. propose that imaging protocols sensitive to changes in vasculature are likely to represent useful predictive markers of malignant lesions that could benefit from radio-embolization.

    • Bruno Morgan
    • Andrew S. Kennedy
    • Ricky A. Sharma
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 8, P: 115-120

  • ‘Hardy’ Helicobacter pylori ecospecies shares the ancestry of ‘Ubiquitous’ H. pylori from the same region in most of the genome but has nearly fixed single-nucleotide polymorphism differences in 100 genes.

    • Elise Tourrette
    • Roberto C. Torres
    • Daniel Falush
    ResearchOpen Access
    Nature
    Volume: 635, P: 178-185

  • Inflammation contributes to the development of metabolic disease through incompletely understood mechanisms. Here the authors report that deletion of the transcription factor KLF2 in myeloid cells leads to increased feeding and weight gain in mice with concomitant peripheral and central tissue inflammation, while overexpression protects against diet-induced metabolic disease.

    • David R. Sweet
    • Neelakantan T. Vasudevan
    • Mukesh K. Jain
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • Analysis of HbA1c and FPG levels across 117 population-based studies demonstrates regional variation in prevalence of previously undiagnosed screen-detected diabetes using one or both measures and suggests that use of elevated FPG alone could underestimate diabetes prevalence in low- and middle-income countries.

    • Bin Zhou
    • Kate E. Sheffer
    • Majid Ezzati
    ResearchOpen Access
    Nature Medicine
    Volume: 29, P: 2885-2901

  • From 1980 to 2018, the levels of total and non-high-density lipoprotein cholesterol increased in low- and middle-income countries, especially in east and southeast Asia, and decreased in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe.

    • Cristina Taddei
    • Bin Zhou
    • Majid Ezzati
    ResearchOpen Access
    Nature
    Volume: 582, P: 73-77

  • Interventional oncology aims to develop new disease-modifying treatment options beyond conventional surgical and oncological therapies. Clinical investigators should incorporate measures of cost-effectiveness and patient-reported outcomes into large-scale studies to provide robust evidence for changing clinical practice. In particular, interventional oncology trials could be designed to show that certain treatments might be as effective as the current standard of care, but with less morbidity and better outcomes for patients with cancer.

    • James M. Franklin
    • Val Gebski
    • Ricky A. Sharma
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 12, P: 93-104

  • Most patients with advanced colorectal cancer die from hepatic metastases. Radioembolization is a technique for administering radiotherapy internally to unresectable primary or secondary hepatic malignancies in a single procedure to improve local control of disease. This technique enables significant downsizing of liver metastases after surgical resection, and the rationale for this approach combined with cytotoxic and molecularly targeted agents is outlined.

    • Nils H. Nicolay
    • David P. Berry
    • Ricky A. Sharma
    Reviews
    Nature Reviews Clinical Oncology
    Volume: 6, P: 687-697

    • Ricky A Sharma
    • Y Sujatha
    Correspondence
    Eye
    Volume: 9, P: 386-387

  • Imaging biomarkers (IBs) are used extensively in drug development and cancer research, but important differences exist between IBs and biospecimen-derived biomarkers. A tailored 'roadmap' is required for the development of new IBs to be used either in clinical research or for decision-making in healthcare. In this Consensus statement, a group of experts assembled by CRUK and the EORTC present 14 key recommendations for accelerating the clinical translation of IBs.

    • James P. B. O'Connor
    • Eric O. Aboagye
    • John C. Waterton
    ReviewsOpen Access
    Nature Reviews Clinical Oncology
    Volume: 14, P: 169-186

  • Can we exploit the DNA repair pathways in cancer cells to increase the efficacy of existing and future cancer treatments? This Review discusses the current state of play.

    • Thomas Helleday
    • Eva Petermann
    • Ricky A. Sharma
    Reviews
    Nature Reviews Cancer
    Volume: 8, P: 193-204

  • Genome sequence data from colorectal tumours show how adenomas progress to carcinomas on the fitness landscape.

    • William Cross
    • Michal Kovac
    • Ian P. M. Tomlinson
    Research
    Nature Ecology & Evolution
    Volume: 2, P: 1661-1672