High-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands suspicious for carcinoma are two prostate cancer diagnoses without standardized follow up and treatment pathways. In this Review, Tosoian and colleagues describe data that have shed light on these phenomena. The improved understanding of the implications of the presence of HGPIN and atypical glands on prostate biopsy means that clinical recommendations can be made for the management of patients with these diagnoses.
- Jeffrey J. Tosoian
- Ridwan Alam
- Jonathan I. Epstein
