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Showing 1–9 of 9 results
Advanced filters: Author: Rie Hamaguchi Clear advanced filters

  • A study from the FANTOM consortium using single-molecule cDNA sequencing of transcription start sites and their usage in human and mouse primary cells, cell lines and tissues reveals insights into the specificity and diversity of transcription patterns across different mammalian cell types.

    • Alistair R. R. Forrest
    • Hideya Kawaji
    • Yoshihide Hayashizaki
    Research
    Nature
    Volume: 507, P: 462-470

  • A total of 1074 patients with a history of ischemic stroke enrolled in The Recurrent Stroke Prevention Clinical Outcome (RESPECT) Study were assigned to intensive blood pressure (BP) control group (blood pressure < 120/80 mmHg) or standard blood pressure control group (blood pressure < 140/90 mmHg) and were followed up for a mean of 3.9 years. Seventy-eight first recurrent strokes occurred, including 70 ischemic stroke and 8 intracerebral hemorrhage. Intensive treatment did not change annual risk of ischemic stroke (1.74% vs. 1.75%, P = 0.999), but markedly reduced risk of hemorrhagic stroke (0.00% vs. 0.39%, P = 0.005). Beneficial effect of intensive BP control were observed for risk of hemorrhagic stroke in the patients with a history of ischemic stroke.

    • Kazuo Kitagawa
    • Hisatomi Arima
    • Seigo Nakada
    Research
    Hypertension Research
    Volume: 45, P: 591-601

  • Yohei Ishibashi and co-workers report that Parietichytrium sp. synthesizes DHA only via the elongase/desaturase pathway. They then engineered this thraustochytrid to produce EPA and n-3DPA by disrupting C20ELO and delta4 DES genes, respectively, in this biosynthetic pathway, suggesting that this may be a suitable system for the large scale production of these omega-3 fatty acids.

    • Yohei Ishibashi
    • Hatsumi Goda
    • Makoto Ito
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11

  • X-ray observations of the core of the Perseus cluster reveal a remarkably quiescent atmosphere in which the gas has a line-of-sight velocity dispersion of about 164 kilometres per second in the region 30–60 kiloparsecs from the central nucleus; turbulent pressure support in the gas is four per cent of the thermodynamic pressure, necessitating only a small correction to the total cluster mass determined from hydrostatic equilibrium.

    • Felix Aharonian
    • Hiroki Akamatsu
    • Abderahmen Zoghbi
    Research
    Nature
    Volume: 535, P: 117-121

  • High-resolution X-ray spectra show near-solar abundances of chromium, manganese and nickel with respect to iron in the Perseus cluster, suggesting that the progenitors of type Ia supernovae could be near- and sub-Chandrasekhar-mass white dwarfs.

    • Felix Aharonian
    • Hiroki Akamatsu
    • Abderahmen Zoghbi
    Research
    Nature
    Volume: 551, P: 478-480