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Showing 1–13 of 13 results
Advanced filters: Author: Rienk Eelkema Clear advanced filters

  • Enzymes regulated by chemical signals are common in biology, but few such artificial catalysts exist. Here, the authors design an aniline catalyst that, when activated by a chemical trigger, catalyses formation of hydrazone-based gels, demonstrating signal response in a soft material.

    • Fanny Trausel
    • Chandan Maity
    • Rienk Eelkema
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-7

  • In situ catalysis of the formation of gelator molecules provides access to metastable gel states with improved mechanical strength compared with uncatalysed gels that have an identical composition. Acid or aniline catalysis enables the formation of hydrogels with tunable gel-strength in a matter of minutes under ambient conditions from simple building blocks.

    • Job Boekhoven
    • Jos M. Poolman
    • Rienk Eelkema
    Research
    Nature Chemistry
    Volume: 5, P: 433-437

  • This Review explores how ionizing radiation triggers drug release via water radiolysis, detailing reactive species, drug activation mechanisms and strategies for designing radiation-sensitive prodrugs and nanocarriers to enhance chemoradiation therapy with reduced systemic toxicity.

    • Juncheng Liu
    • Antonia G. Denkova
    • Rienk Eelkema
    Reviews
    Nature Reviews Chemistry
    Volume: 10, P: 72-87

  • A molecular motor in a liquid-crystal film uses light to turn items thousands of times larger than itself.

    • Rienk Eelkema
    • Michael M. Pollard
    • Ben L. Feringa
    Research
    Nature
    Volume: 440, P: 163

  • Reaction-diffusion controls the spatial formation of many natural structures but is rarely applied to organic materials. Here, the authors couple reaction-diffusion to the self-assembly of a supramolecular gelator, introducing a strategy to forming soft, free-standing objects with controlled shape and functionality.

    • Matija Lovrak
    • Wouter E. J. Hendriksen
    • Jan H. van Esch
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Out of equilibrium operation of chemical reaction networks. (CRNs) enables materials to autonomously respond to their environment by activation and deactivation of intermolecular interactions but the deactivation to noninteracting building blocks remains understudied. Here, the authors develop a new, modular CRN that enables control over the deactivation kinetics.

    • Benjamin Klemm
    • Reece W. Lewis
    • Rienk Eelkema
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • The application of organocatalysis in biology is still in its infancy. In this Review, we evaluate organocatalytic reactions in terms of their applicability in biological settings, including new technologies in chemical biology and biomedicine.

    • Michelle P. van der Helm
    • Benjamin Klemm
    • Rienk Eelkema
    Reviews
    Nature Reviews Chemistry
    Volume: 3, P: 491-508

  • This Perspective describes new single-molecule protein sequencing and identification technologies alongside innovations in mass spectrometry that will eventually enable broad sequence coverage in single-cell proteomics.

    • Javier Antonio Alfaro
    • Peggy Bohländer
    • Chirlmin Joo
    Reviews
    Nature Methods
    Volume: 18, P: 604-617