Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–7 of 7 results
Advanced filters: Author: Riffat Ahmed Clear advanced filters

  • Genome-wide analysis of matched human IVF embryonic stem cells (IVF ES cells), induced pluripotent stem cells (iPS cells) and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear transfer (SCNT) reveals that human somatic cells can be faithfully reprogrammed to pluripotency by SCNT; NT ES cells and iPS cells derived from the same somatic cells contain comparable numbers of de novo copy number variations, but whereas DNA methylation and transcriptome profiles of NT ES cells and IVF ES cells are similar, iPS cells have residual patterns typical of parental somatic cells.

    • Hong Ma
    • Robert Morey
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 511, P: 177-183

  • CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 548, P: 413-419

    • Hong Ma
    • Nuria Marti-Gutierrez
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 560, P: E10-E23

  • Analysis of mitochondrial replacement therapy shows, even with efficient mutant mitochondrial DNA replacement and maintenance in embryonic stem cells, a gradual loss of donor mitochondrial DNA in some lines owing to a polymorphism in the D-loop, potentially causing preferential replication of specific mitochondrial DNA haplotypes.

    • Eunju Kang
    • Jun Wu
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 540, P: 270-275

  • Mutations in mitochondrial (mt)DNA are associated with severe disorders for which treatment is currently limited; this study shows that mtDNA mutations can be genetically corrected and normal metabolic function restored in cells derived from patients with mtDNA disease and reprogrammed to pluripotency through factor-mediated reprogramming or via a somatic cell nuclear transfer approach.

    • Hong Ma
    • Clifford D. L. Folmes
    • Shoukhrat Mitalipov
    Research
    Nature
    Volume: 524, P: 234-238