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BRAF^V600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Senescence of hematopoietic progenitor cells, enforced by the BRAF^V600E mutation, underlies the development of Langerhans cell histiocytosis and could be a new target for drug development and therapy of this disease in patients.

Camille Bigenwald
Jessica Le Berichel
Miriam Merad
Research06 May 2021
Nature Medicine

Volume: 27, P: 851-861
Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial

In this phase 1 trial, Hegde et al. treat 13 individuals with advanced sarcoma with lymphodepletion followed by HER2-specific CAR T cells, which were found to be safe and showed antitumor activity.

Meenakshi Hegde
Shoba Navai
Nabil Ahmed
Research24 Apr 2024
Nature Cancer

Volume: 5, P: 880-894

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BRAFV600E-induced senescence drives Langerhans cell histiocytosis pathophysiology

Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial

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BRAF^V600E-induced senescence drives Langerhans cell histiocytosis pathophysiology