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Showing 1–3 of 3 results
Advanced filters: Author: Rimma Goldberg Clear advanced filters
  • Although available clinical outcome data are reassuring, the consequences of in utero exposure to inflammatory bowel disease (IBD) pharmacotherapies on the development of the neonatal immune system remain ill-defined. So too does the converse effect on immunological maturation of fetal exposure to maternal inflammatory activity. Both warrant elucidation to appropriately stratify antenatal IBD care.

    • Ralley E. Prentice
    • Sally J. Bell
    • Rimma Goldberg
    Comments & Opinion
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 213-214
  • Necrotizing Enterocolitis (NEC) is an untreatable intestinal disease in infants. Here the authors show that human and experimental mouse NEC is associated with altered toll-like receptor expression in the intestine, enhanced Th17/type 3 polarization in adaptive immune and innate lymphoid cells, dysregulated microbiota, and reduced interleukin-37 signaling.

    • Steven X. Cho
    • Ina Rudloff
    • Marcel F. Nold
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-19
  • A novel family of innate lymphocytes called innate lymphoid cells (ILCs) have been found to accumulate in mucosal tissue and produce cytokines relevant to IBD. This Review describes the subsets of ILCs, how they are involved in IBD pathogenesis and ways in which they reveal new therapeutic targets for IBD treatment.

    • Rimma Goldberg
    • Natalie Prescott
    • Nick Powell
    Reviews
    Nature Reviews Gastroenterology & Hepatology
    Volume: 12, P: 271-283