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Showing 1–2 of 2 results
Advanced filters: Author: Ritwij Kulkarni Clear advanced filters

  • The lipocalin protein Scn-Ngal is known to bind iron-chelating siderophores, leading to inhibition of bacterial growth. New results reveal that Scn-Ngal, in the absence of bacterial infection, can form a complex with catechol that binds and transports iron in vivo.

    • Guanhu Bao
    • Matthew Clifton
    • Jonathan Barasch
    Research
    Nature Chemical Biology
    Volume: 6, P: 602-609

  • The current diagnosis of acute kidney injury involves the measurement of renal biomarkers, such as serum creatinine, which provide a crude means of detecting cellular stress and injury. To determine whether Ngal expression provides an alternate renal biomarker capable of detecting the initial phases of renal injury, Paragas et al. have developed an Ngal reporter mouse that offers a noninvasive and real-time method for the continuous and quantitative reporting of cell stress and injury at the injury site.

    • Neal Paragas
    • Andong Qiu
    • Jonathan Barasch
    Research
    Nature Medicine
    Volume: 17, P: 216-222