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Showing 1–7 of 7 results
Advanced filters: Author: Rob C. Oslund Clear advanced filters

  • Studies of histidine phosphorylation have been limited owing to a lack of appropriate tools. The synthesis of a stable phosphohistidine mimic now leads to a pan antibody, enabling detection and further functional investigations of this little-known post-translational modification.

    • Jung-Min Kee
    • Rob C Oslund
    • Tom W Muir
    Research
    Nature Chemical Biology
    Volume: 9, P: 416-421

  • Bisphosphoglycerate mutase (BPGM) drives phosphoglycerate mutase 1 (PGAM1) phosphorylation, which is required for glycolytic flux. Loss of BPGM is partially compensated by 1,3-BPG directly phosphorylating PGAM1, sustaining glycolytic flux but diverting metabolites for serine synthesis.

    • Rob C Oslund
    • Xiaoyang Su
    • Joshua D Rabinowitz
    Research
    Nature Chemical Biology
    Volume: 13, P: 1081-1087

  • The covalent capture of a ligand by its target protein(s) is important for drug-target identification. Now an electrochemically active warhead—diazetidinone—can be leveraged in a chemoproteomics platform for electroaffinity labelling of a ligand’s target protein to afford target-ligand identification in live cells.

    • Yu Kawamata
    • Keun Ah Ryu
    • Phil S. Baran
    Research
    Nature Chemistry
    Volume: 15, P: 1267-1275

  • Technologies for profiling biological environments with high spatiotemporal resolution are in demand to enable the discovery of new targets for addressing unmet clinical needs. Now, a deep red light-mediated photocatalytic strategy for the targeted activation of aryl azides has been developed. This platform enables mapping of protein microenvironments in physiologically relevant systems.

    • Nicholas Eng Soon Tay
    • Keun Ah Ryu
    • Tomislav Rovis
    Research
    Nature Chemistry
    Volume: 15, P: 101-109

  • A new targeting modality-based transcellular labeling technology called photocatalytic cell tagging enables monitoring of cell–cell interactions when combined with multiomics single-cell sequencing.

    • Rob C. Oslund
    • Tamara Reyes-Robles
    • Olugbeminiyi O. Fadeyi
    Research
    Nature Chemical Biology
    Volume: 18, P: 850-858

  • Cell–cell interactions and resulting signaling events drive key biological processes. This Review discusses the deconvolution of this complex biology through the development of tools for visualizing, chemically tagging and functionally exploiting these interactions.

    • Tyler J. Bechtel
    • Tamara Reyes-Robles
    • Rob C. Oslund
    Reviews
    Nature Chemical Biology
    Volume: 17, P: 641-652

  • Photocatalysis is widely used in numerous fields, including chemistry and biology. This Review highlights the impact of photosensitization and photoredox photocatalysis within therapeutic development, bioconjugation and for probing complex cellular environments.

    • Keun Ah Ryu
    • Christina M. Kaszuba
    • Olugbeminiyi O. Fadeyi
    Reviews
    Nature Reviews Chemistry
    Volume: 5, P: 322-337