Nature Search

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA

Annemieke de Vries
Conny Th. M. van Oostrom
Sjef J. Verbeek
Research14 Sept 1995
Nature

Volume: 377, P: 169-173
Independent replication and expression of B-component RNA of cowpea mosaic virus

Rob Goldbach
Geertje Rezelman
Albert van Kammen
Research17 Jul 1980
Nature

Volume: 286, P: 297-300
Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

Beatriz Nuez
Dave Michalovich
Frank Grosveld
Research25 May 1995
Nature

Volume: 375, P: 316-318
Diminishing benefits of urban living for children and adolescents’ growth and development

The advantage of living in cities compared with rural areas with respect to height and BMI in children and adolescents has generally become smaller globally from 1990 to 2020, except in sub-Saharan Africa.

Anu Mishra
Bin Zhou
Majid Ezzati
ResearchOpen Access29 Mar 2023
Nature

Volume: 615, P: 874-883
Cytotoxic T cells are able to efficiently eliminate cancer cells by additive cytotoxicity

Cytotoxic CD8⁺ T lymphocytes (CTL) often fail to kill tumour cells in one-to-one interactions. Here the authors show that these sublethal interactions from multiple CTL can add up over time and achieve tumour cell killing by additive cytotoxicity.

Bettina Weigelin
Annemieke Th. den Boer
Peter Friedl
ResearchOpen Access01 Sept 2021
Nature Communications

Volume: 12, P: 1-12
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Limited CD4⁺ T-cell renewal in early HIV-1 infection: Effect of highly active antiretroviral therapy

We show that the fraction of proliferating CD4⁺ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4⁺ T cells associated with the restoration of CD4⁺ T-cell counts. These results provide strong support for the idea of limited CD4⁺ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4⁺ T-cell production are still functional in early HIV infection.

Sylvain Fleury
Rob J. De Boer
Giuseppe Pantaleo
Research01 Jul 1998
Nature Medicine

Volume: 4, P: 794-801
The Birth of a Relativistic Jet Following the Disruption of a Star by a Cosmological Black Hole

By modelling the radio, optical, UV and X-ray data of the unusually bright cosmological explosion AT 2022cmc, Pasham et al. argue for the presence of a highly collimated jet moving at ≳99.99% the speed of light.

Dheeraj R. Pasham
Matteo Lucchini
Sheng Yang
Research30 Nov 2022
Nature Astronomy

Volume: 7, P: 88-104
HIV-1 CCR5 gene therapy will fail unless it is combined with a suicide gene

Aridaman Pandit
Rob J. de Boer
ResearchOpen Access17 Dec 2015
Scientific Reports

Volume: 5, P: 1-7
Author Correction: Replicative history marks transcriptional and functional disparity in the CD8⁺ T cell memory pool

Kaspar Bresser
Lianne Kok
Ton N. Schumacher
Amendments and Corrections23 May 2022
Nature Immunology

Volume: 23, P: 1132
Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

In this case study of a patient with fracture-related pandrug-resistant Klebsiella pneumoniae infection after long-term antibiotic therapy, the authors use a combination therapy of pre-adapted bacteriophage and antibiotics resulting in clinical, microbiological and radiological improvement.

Anaïs Eskenazi
Cédric Lood
Jean-Paul Pirnay
ResearchOpen Access18 Jan 2022
Nature Communications

Volume: 13, P: 1-14
Soil networks become more connected and take up more carbon as nature restoration progresses

Effects of habitat restoration on belowground organisms and ecosystem processes are poorly understood. Morriën and colleagues show that changes in the composition and network interactions of soil biota lead to improved carbon uptake efficiency when formerly cultivated land is restored.

Elly Morriën
S. Emilia Hannula
Wim H. van der Putten
ResearchOpen Access08 Feb 2017
Nature Communications

Volume: 8, P: 1-10
Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

Nadine G. Pakker
Daan W. Notermans
Peter T.A. Schellekens
Research01 Feb 1998
Nature Medicine

Volume: 4, P: 208-214
9 THE EFFECT OF GASTRIC PH ON THE ABSORPTION OF KETOCONAZOLE BY VERY-LOW-BIRTH-WEIGHT INFANTS

John N Van Den Anker
Ania Van Ussel-Dijk
Pieter J J Sauer
Research01 Jul 1994
Pediatric Research

Volume: 36, P: 4
Seventy-five genetic loci influencing the human red blood cell

A series of genetic studies have led to the discovery of novel independent loci and candidate genes associated with red blood cell phenotype; for a proportion of these genes potential single-nucleotide genetic variants are also identified, providing new insights into genetic pathways controlling red blood cell formation, function and pathology.

Pim van der Harst
Weihua Zhang
John C. Chambers
Research05 Dec 2012
Nature

Volume: 492, P: 369-375
ELOF1 is a transcription-coupled DNA repair factor that directs RNA polymerase II ubiquitylation

Two side-by-side papers report that the transcription elongation factor ELOF1 drives transcription-coupled repair and prevents replication stress.

Yana van der Weegen
Klaas de Lint
Martijn S. Luijsterburg
Research09 Jun 2021
Nature Cell Biology

Volume: 23, P: 595-607
Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection

Mette D. Hazenberg
Sigrid A. Otto
Frank Miedema
Research01 Sept 2000
Nature Medicine

Volume: 6, P: 1036-1042
Replicative history marks transcriptional and functional disparity in the CD8⁺ T cell memory pool

Schumacher and colleagues have designed a reporter system that allows in vivo tracking of replicative history over many cell generations. Using this system to study acute T cell responses, they uncover substantial diversity in past division of central memory CD8⁺ T cells and its link to cell state and recall potential.

Kaspar Bresser
Lianne Kok
Ton N. Schumacher
Research07 Apr 2022
Nature Immunology

Volume: 23, P: 791-801
NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

William Evans and colleagues find that the proinflammatory genes CASP1 and NLRP3 are expressed at higher levels in primary acute lymphoblastic leukemia cells that are resistant than in those that are sensitive to glucocorticoid treatment. They find that CASP1 mediates glucocorticoid resistance through cleavage of the glucocorticoid receptor.

Steven W Paugh
Erik J Bonten
William E Evans
Research04 May 2015
Nature Genetics

Volume: 47, P: 607-614
How lymphocytes add up

A surprising molecular mechanism underlying signal integration and programmed proliferation in adaptive immunity has been identified: the cell-cycle regulator Myc enables a lymphocyte to add up the strength of signals it receives and time its response accordingly.

Becca Asquith
Rob J de Boer
News & Views16 Dec 2016
Nature Immunology

Volume: 18, P: 12-13
Long-term adaptation of the influenza A virus by escaping cytotoxic T-cell recognition

Rutger G. Woolthuis
Christiaan H. van Dorp
Michiel van Boven
ResearchOpen Access15 Sept 2016
Scientific Reports

Volume: 6, P: 1-8
Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation

John Chambers, Jaspal Kooner, Pim van der Harst, Shyong Tai, Paul Elliott, Jiang He, Norihiro Kato and colleagues performed a genome-wide association study of blood pressure phenotypes in individuals of European, East Asian and South Asian ancestry. They find trait-associated SNPs at 12 loci, some of which are associated with methylation at nearby CpG sites.

Norihiro Kato
Marie Loh
John C Chambers
Research21 Sept 2015
Nature Genetics

Volume: 47, P: 1282-1293
DNA damage in transcribed genes induces apoptosis via the JNK pathway and the JNK-phosphatase MKP-1

Mohamed Hamdi
Jaap Kool
Hans van Dam
Research25 Jul 2005
Oncogene

Volume: 24, P: 7135-7144
Favorable outcome of NUTM1-rearranged infant and pediatric B cell precursor acute lymphoblastic leukemia in a collaborative international study

Judith M. Boer
Maria Grazia Valsecchi
Rob Pieters
ResearchOpen Access01 Jul 2021
Leukemia

Volume: 35, P: 2978-2982
Transdisciplinary EU science institute needs funds urgently

Jan W. Vasbinder
Bertil Andersson
Rein Willems
Correspondence17 Feb 2010
Nature

Volume: 463, P: 876
Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Little is known about the biology of back pain, a leading cause of disability. Here the authors report 30 new back pain loci, implicating genes involved in cartilage/bone biology, as well as neurological and inflammatory processes.

Gyda Bjornsdottir
Lilja Stefansdottir
Kari Stefansson
ResearchOpen Access02 Feb 2022
Nature Communications

Volume: 13, P: 1-13
Relapse to Cocaine- and Heroin-Seeking Behavior Mediated by Dopamine D2 Receptors Is Time-Dependent and Associated with Behavioral Sensitization

Taco J De Vries
Anton N M Schoffelmeer
Louk J M J Vanderschuren
Research25 May 2001
Neuropsychopharmacology

Volume: 26, P: 18-26
Integration of genetics and MRD to define low risk patients with B-cell precursor acute lymphoblastic leukaemia with intermediate MRD levels at the end of induction

Anthony V. Moorman
Amir Enshaei
Mats Heyman
ResearchOpen Access05 Jul 2024
Leukemia

Volume: 38, P: 2023-2026
Dietary glycemic index in relation to metabolic risk factors and incidence of coronary heart disease: the Zutphen Elderly Study

RM van Dam
AWJ Visscher
D Kromhout
Research13 Sept 2000
European Journal of Clinical Nutrition

Volume: 54, P: 726-731
Thymic output: a bad TREC record

TREC assays are used to detect recent thymic emigrants and quantitate thymic output. However, the longevity of naive T cells combined with T cell division suggest TREC data should be interpreted with caution.

Mette D. Hazenberg
José A.M. Borghans
Frank Miedema
Comments & Opinion01 Feb 2003
Nature Immunology

Volume: 4, P: 97-99
Analysing immune cell migration

Time-lapse video microscopy is an important experimental tool for examining the dynamic behaviour of immune cellsin situand involves quantitative analysis of cell migration and cell–cell interactions. Here, several commonly measured parameters and imaging artefacts are described and potential solutions to detect and correct these artefacts are proposed.

Joost B. Beltman
Athanasius F. M. Marée
Rob J. de Boer
Reviews16 Oct 2009
Nature Reviews Immunology

Volume: 9, P: 789-798
Diverse and heritable lineage imprinting of early haematopoietic progenitors

In vivo ‘cellular barcoding’ shows that early haematopoietic progenitors are heterogeneous in the cell types that they produce, and this is partly due to an ‘imprinting’ of fate in progenitors, including for a separate dendritic cell lineage.

Shalin H. Naik
Leïla Perié
Ton N. Schumacher
Research03 Apr 2013
Nature

Volume: 496, P: 229-232
BEHAV3D: a 3D live imaging platform for comprehensive analysis of engineered T cell behavior and tumor response

BEHAV3D is a 3D live imaging platform for analyzing engineered T cell behavior and tumor response. This provides insights into the mode of action of cellular immunotherapy, capturing heterogeneity within and between tumors during treatment response.

Maria Alieva
Mario Barrera Román
Anne C. Rios
Protocols19 Mar 2024
Nature Protocols

Volume: 19, P: 2052-2084
Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia

Elisabeth M. P. Steeghs
Judith M. Boer
Monique L. den Boer
ResearchOpen Access15 Mar 2019
Scientific Reports

Volume: 9, P: 1-11
High STAP1 expression in DUX4-rearranged cases is not suitable as therapeutic target in pediatric B-cell precursor acute lymphoblastic leukemia

Elisabeth M. P. Steeghs
Marjolein Bakker
Monique L. den Boer
ResearchOpen Access12 Jan 2018
Scientific Reports

Volume: 8, P: 1-13
A complete chromosome substitution mapping panel reveals genome-wide epistasis in Arabidopsis

Cris L. Wijnen
Ramon Botet
Joost J. B. Keurentjes
ResearchOpen Access09 Jul 2024
Heredity

Volume: 133, P: 198-205
Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology

Gyda Bjornsdottir
Lilja Stefansdottir
Kari Stefansson
Amendments and CorrectionsOpen Access27 Apr 2022
Nature Communications

Volume: 13, P: 1-3
Chemopreventive targeted treatment of head and neck precancer by Wee1 inhibition

Anne M. van Harten
D. Vicky de Boer
Ruud H. Brakenhoff
ResearchOpen Access11 Feb 2020
Scientific Reports

Volume: 10, P: 1-12
The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Kasper Recourt
Peter de Boer
Wayne Drevets
ResearchOpen Access03 Sept 2019
Translational Psychiatry

Volume: 9, P: 1-10
Correction to: The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder

Kasper Recourt
Peter de Boer
Wayne Drevets
Amendments and CorrectionsOpen Access02 Oct 2019
Translational Psychiatry

Volume: 9, P: 1
Bacteriophage ISP eliminates Staphylococcus aureus in planktonic phase, but not in the various stages of the biofilm cycle

Mariëlle Verheul
Aat A. Mulder
Peter H. Nibbering
ResearchOpen Access22 Jun 2024
Scientific Reports

Volume: 14, P: 1-11
Evaluation of pliable bioresorbable, elastomeric aortic valve prostheses in sheep during 12 months post implantation

In situ tissue engineered heart valve prostheses implanted in aortic position of an ovine model up to 12 months meet several hallmarks for sustainable heart valves prostheses, but variability in tissue remodelling and valve functionality are seen.

Annemijn Vis
Bente J. de Kort
Jolanda Kluin
ResearchOpen Access14 Nov 2023
Communications Biology

Volume: 6, P: 1-14
Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients

Yvette den Hartog
S. Reshwan K. Malahe
Rob van Binnendijk
ResearchOpen Access14 Feb 2024
npj Viruses

Volume: 2, P: 1-10
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index

A Hinney
M Kesselmeier
J Hebebrand
Research17 May 2016
Molecular Psychiatry

Volume: 22, P: 192-201
ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

Ali Abbas
Sheryl Ann Abdukahil
Luis Felipe Reyes
ResearchOpen Access30 Jul 2022
Scientific Data

Volume: 9, P: 1-22
Effective early antiretroviral therapy in perinatal-HIV infection reduces subsequent plasma inflammatory profile

Athena N. Nguyen
Alec L. Plotkin
Cissy Kityo
Research13 Jun 2023
Pediatric Research

Volume: 94, P: 1667-1674

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