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Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth

During filamentous growth in the human fungal pathogen Candida albicans, a reduction in ribosome concentration leads to a decrease in macromolecular crowding. Inhibition of ribosome biogenesis can trigger filamentous growth in this pathogen.

Antonio Serrano
Charles Puerner
Robert Alan Arkowitz
Research10 Dec 2025
Nature Microbiology

Volume: 11, P: 169-179
A GTP-exchange factor required for cell orientation

Aljoscha Nern
Robert A. Arkowitz
Research08 Jan 1998
Nature

Volume: 391, P: 195-198

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Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth

A GTP-exchange factor required for cell orientation

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