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Showing 1–9 of 9 results
Advanced filters: Author: Robert A. Reenan Clear advanced filters

  • The Hoppel transposable element mediates heterochromatin formation in Drosophila. Here Savva et al. report that the RNA-editing enzyme, ADAR, edits a long double-stranded RNA generated by the Hoppeltransposon, thereby regulating heterochromatin formation and gene expression.

    • Yiannis A. Savva
    • James E. C. Jepson
    • Robert A. Reenan
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • Adenosine-to-inosine RNA editing modifies expressed sequences and enhances functional protein diversity. The authors report an in vivo fluorescent reporter that provides a readout of adenosine deaminase RNA-editing activity in Drosophila melanogaster neurons, showing evidence of inter-individual variability in editing activity.

    • James E C Jepson
    • Yiannis A Savva
    • Robert A Reenan
    Research
    Nature Methods
    Volume: 9, P: 189-194

  • Adars are adenosine deaminases that act on RNAs, including those encoding proteins involved in neuronal transmission and also Adar RNA. Here, Savvaet al. engineered knock-in Drosophila mutants with altered Adar autoediting and found that this changed the spectrum of adenosine deamination and Drosophilabehaviour.

    • Yiannis A. Savva
    • James E.C Jepson
    • Robert A. Reenan
    Research
    Nature Communications
    Volume: 3, P: 1-10

  • A central, imperfect duplex RNA secondary structure is generally required for site-specific adenosine-to-inosine RNA editing by ADAR enzymes. Rieder et al. show in Drosophila that conserved and complex long-range RNA tertiary structures form in vivoand can also regulate specific RNA-editing events by ADAR enzymes.

    • Leila E. Rieder
    • Cynthia J. Staber
    • Robert A. Reenan
    Research
    Nature Communications
    Volume: 4, P: 1-11

  • The accurate and thorough genome-wide detection of A-to-I editing has proven technically challenging. Using a combination of computational prediction and experimental validation, the authors report ~3,500 high-probability editing sites with sufficient accuracy to reveal the global patterns underlying biological functions of RNA editing in adult male Drosophila melanogaster.

    • Georges St Laurent
    • Michael R Tackett
    • Robert A Reenan
    Research
    Nature Structural & Molecular Biology
    Volume: 20, P: 1333-1339

  • An international consortium reports the genomic sequence for ten Drosophila species, and compares them to two other previously published Drosophila species. These data are invaluable for drawing evolutionary conclusions across an entire phylogeny of species at once.

    • Andrew G. Clark
    • Michael B. Eisen
    • Iain MacCallum
    Research
    Nature
    Volume: 450, P: 203-218

  • Loss of FMR1 gene function results in fragile X syndrome. Here, the authors demonstrate that the Drosophila fragile X homolog dFMR1 is involved in the RNA editing pathway via interaction with the enzyme dADAR and suggest that proper NMJ synaptic architecture requires modulation of dADAR activity by dFMR1.

    • Balpreet Bhogal
    • James E Jepson
    • Thomas A Jongens
    Research
    Nature Neuroscience
    Volume: 14, P: 1517-1524