Nature Search

Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

Many genetic variants have been associated with human traits, but the mechanism is often unknown. Here, the authors integrate local and distal genetic associations with multi-omics datasets to provide a roadmap to understand the underlying mechanisms of GWAS variants on complex traits.

Andrew A. Brown
Juan J. Fernandez-Tajes
Ana Viñuela
ResearchOpen Access21 Aug 2023
Nature Communications

Volume: 14, P: 1-17
Data-driven cluster analysis identifies distinct types of metabolic dysfunction-associated steatotic liver disease

Partitioning clustering based on clinical variables applied to multiple patient cohorts identifies two subtypes of metabolic dysfunction-associated steatotic liver disease with different associations to hepatic and cardiovascular outcomes.

Violeta Raverdy
Federica Tavaglione
François Pattou
ResearchOpen Access09 Dec 2024
Nature Medicine

Volume: 30, P: 3624-3633
Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH

GDF-15 is a cytokine regulating food intake and a potential therapeutic target for treating obesity. Here, the authors show that macrophage infiltration in adipose tissue increases GDF-15 during obesity and type 2 diabetes, and hepatocyte stress further increases its levels when developing MASH.

Laurent L’homme
Benan Pelin Sermikli
David Dombrowicz
ResearchOpen Access21 Aug 2024
Nature Communications

Volume: 15, P: 1-18
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Bile acids exert metabolic effects by modulating FXR receptor activity. Here, Trabelsi et al.show that FXR negatively regulates production of the incretin GLP-1 in enteroendocrine L-cells by reducing glycolysis and that inhibition of FXR improves glucose metabolism by increasing GLP-1 in obese mice.

Mohamed-Sami Trabelsi
Mehdi Daoudi
Sophie Lestavel
Research02 Jul 2015
Nature Communications

Volume: 6, P: 1-13
A 62-minute orbital period black widow binary in a wide hierarchical triple

ZTF J1406+1222 is a wide hierarchical triple system that hosts a low-metallicity subdwarf star and a ‘black widow’ millisecond pulsar that has a highly varying optical flux and a 62-minute period.

Kevin B. Burdge
Thomas R. Marsh
Thomas A. Prince
Research04 May 2022
Nature

Volume: 605, P: 41-45
A dense 0.1-solar-mass star in a 51-minute-orbital-period eclipsing binary

A 51-minute-orbital-period, fully eclipsing binary system consisting of a star with a comparable temperature to that of the Sun but a 100 times greater density, accreting onto a white dwarf is reported.

Kevin B. Burdge
Kareem El-Badry
Thomas A. Prince
Research05 Oct 2022
Nature

Volume: 610, P: 467-471
Functional genomics uncovers the transcription factor BNC2 as required for myofibroblastic activation in fibrosis

Myofibroblasts contribute to the development of liver fibrosis. Here, the authors report that the transcription factor Basonuclin 2 (BNC2) integrates fibrogenic signals and drives myofibroblastic transcriptional activation in liver fibrosis.

Marie Bobowski-Gerard
Clémence Boulet
Jérôme Eeckhoute
ResearchOpen Access10 Sept 2022
Nature Communications

Volume: 13, P: 1-20
Peroxisomal β-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis

Ding et al. report a mechanism that allows cells to sense cellular fatty acid levels and adjust lipolysis as needed, which involves peroxisomal degradation of fatty acids, production of reactive oxygen species and post-translational regulation of adipose triglyceride lipase.

Lianggong Ding
Wenfei Sun
Christian Wolfrum
ResearchOpen Access13 Dec 2021
Nature Metabolism

Volume: 3, P: 1648-1661
Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Clinical multi-omics data are integrated and analyzed using a generative deep-learning model.

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
ResearchOpen Access02 Jan 2023
Nature Biotechnology

Volume: 41, P: 399-408
Low copy number of the salivary amylase gene predisposes to obesity

Mario Falchi, Philippe Froguel and colleagues report association of a multi-allelic copy number variant encompassing the salivary amylase gene AMY1 with body mass index and risk of obesity.

Mario Falchi
Julia Sarah El-Sayed Moustafa
Philippe Froguel
Research30 Mar 2014
Nature Genetics

Volume: 46, P: 492-497
A reference map of potential determinants for the human serum metabolome

The levels of 1,251 metabolites are measured in 475 phenotyped individuals, and machine-learning algorithms reveal that diet and the microbiome are the determinants with the strongest predictive power for the levels of these metabolites.

Noam Bar
Tal Korem
Eran Segal
Research11 Nov 2020
Nature

Volume: 588, P: 135-140
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

Mice deficient in the lipid sensor GPR120 develop obesity, glucose intolerance and fatty liver when fed a high-fat diet, and a loss-of-function variant in the GPR120 gene strongly contributes to increased obesity in human.

Atsuhiko Ichimura
Akira Hirasawa
Philippe Froguel
Research19 Feb 2012
Nature

Volume: 483, P: 350-354
Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

Rosa Lundbye Allesøe
Agnete Troen Lundgaard
Moustafa Abdalla
Amendments and CorrectionsOpen Access02 May 2023
Nature Biotechnology

Volume: 41, P: 1026
IFNγ-producing NK cells in adipose tissue are associated with hyperglycemia and insulin resistance in obese women

Denis A. Mogilenko
Robert Caiazzo
David Dombrowicz
Research01 May 2021
International Journal of Obesity

Volume: 45, P: 1607-1617

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