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Showing 1–2 of 2 results
Advanced filters: Author: Robert Düster Clear advanced filters

  • Cyclin-dependent kinase 7 (Cdk7) is required in cell-cycle and transcriptional regulation. It is regulated by two phosphorylations in the activation segment. Here, the authors report a structure of the human Cdk7/Cyclin H/Mat1 complex containing both phosphorylations, with further insights into the regulatory mechanisms.

    • Robert Düster
    • Kanchan Anand
    • Matthias Geyer
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • Abemaciclib is a third generation CDK-directed drug used in the treatment of HR + /HER2 negative advanced or metastatic breast cancer. Here the authors demonstrate that members of the Homeodomain-interacting protein kinases (HIPKs) HIPK3 and DYRK1A are also targeted by Abemaciclib.

    • Ines H. Kaltheuner
    • Kanchan Anand
    • Matthias Geyer
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15