In addition to their cytotoxic, inflammatory and immunoregulatory functions, neutrophils are implicated in the pathogenesis of several autoimmune diseases, including rheumatoid arthritis. This article highlights the contributions of neutrophils to the pathophysiology of rheumatoid arthritis, focusing on the generation of autoantigens resulting from the release of neutrophil extracellular traps.
- Helen L. Wright
- Robert J. Moots
- Steven W. Edwards
