Marc Ladanyi and colleagues show that the nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma (MPM). They further show that knockdown of BAP1 in MPM cell lines affects E2F and Polycomb target genes, implicating transcriptional deregulation in disease pathogenesis.
- Matthew Bott
- Marie Brevet
- Marc Ladanyi
