Chemokines control key immunological processes by signalling through G protein-coupled receptors. In addition, chemokines can be bound by atypical chemokine receptors (ACKRs), which are structurally related to conventional chemokine receptors, but which do not mediate classical signalling responses. This Review describes the biological functions of ACKRs and introduces the new nomenclature that has been proposed for this family.
- Robert J. B. Nibbs
- Gerard J. Graham
