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Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits

Dopaminergic circuits are implicated in exploratory motor behaviour and are modulated by acetylcholine. Using transgenic mouse models, Patelet al. find that loss of forebrain acetylcholine results in exaggerated dopamine efflux and hyperactivity, whereas loss of brainstem acetylcholine leads to hypoactivity.

Jyoti C. Patel
Elsa Rossignol
Robert P. Machold
Research06 Nov 2012
Nature Communications

Volume: 3, P: 1-10
Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex

Spikes of deep-layer ID2⁺Nkx2.1⁺ cortical neurons are anticorrelated with spiking of all principal cells and interneurons, prominently during down states of sleep, and shape the sequential firing of neurons at down–up transitions.

Manuel Valero
Tim J. Viney
György Buzsáki
Research22 Feb 2021
Nature Neuroscience

Volume: 24, P: 401-411
FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

Cortical excitatory/inhibitory (E/I) imbalance is a feature of autism spectrum disorder (ASD). Here, the authors show that FoxG1 regulates the formation of cortical GABAergic circuits affecting social behaviour during a specific postnatal time window in mouse models of ASD.

Goichi Miyoshi
Yoshifumi Ueta
Mariko Miyata
ResearchOpen Access18 Jun 2021
Nature Communications

Volume: 12, P: 1-17
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Insulin signals satiety after a meal; however, the rising incidence of obesity and chronic insulin elevation suggests that insulin may also signal reward. Here, Stouffer et al. show that insulin amplifies dopamine release in rodent striatum depending on diet, and that striatal insulin can influence food choice.

Melissa A. Stouffer
Catherine A. Woods
Margaret E. Rice
ResearchOpen Access27 Oct 2015
Nature Communications

Volume: 6, P: 1-12
Single-cell delineation of lineage and genetic identity in the mouse brain

Single-cell RNA sequencing with parallel tagging of progenitor cells is used to track clonal relationships and transcriptomic signatures during development of the mouse forebrain.

Rachel C. Bandler
Ilaria Vitali
Christian Mayer
ResearchOpen Access15 Dec 2021
Nature

Volume: 601, P: 404-409
Developmental diversification of cortical inhibitory interneurons

The embryonic emergence of interneuron subtypes in mice is revealed by integrated single-cell transcriptomic analysis along a developmental time course.

Christian Mayer
Christoph Hafemeister
Rahul Satija
Research05 Mar 2018
Nature

Volume: 555, P: 457-462
Innovations present in the primate interneuron repertoire

Single-nucleus RNA-sequencing analyses of brain from humans, macaques, marmosets, mice and ferrets reveal diverse ways that interneuron populations have changed during evolution.

Fenna M. Krienen
Melissa Goldman
Steven A. McCarroll
Research30 Sept 2020
Nature

Volume: 586, P: 262-269

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Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits

Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex

FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Single-cell delineation of lineage and genetic identity in the mouse brain

Developmental diversification of cortical inhibitory interneurons

Innovations present in the primate interneuron repertoire

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Opposing regulation of dopaminergic activity and exploratory motor behavior by forebrain and brainstem cholinergic circuits

Sleep down state-active ID2/Nkx2.1 interneurons in the neocortex

FoxG1 regulates the formation of cortical GABAergic circuit during an early postnatal critical period resulting in autism spectrum disorder-like phenotypes

Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward

Single-cell delineation of lineage and genetic identity in the mouse brain

Developmental diversification of cortical inhibitory interneurons

Innovations present in the primate interneuron repertoire

Search

Quick links