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Polygenic prediction of body mass index and obesity through the life course and across ancestries

Polygenic scores for body mass index and obesity constructed using data from 5 million people with different ancestries were associated with distinct weight gain trajectories from early childhood to adulthood.

Roelof A. J. Smit
Kaitlin H. Wade
Ruth J. F. Loos
ResearchOpen Access21 Jul 2025
Nature Medicine

Volume: 31, P: 3151-3168
Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Systemic modulation of branched-chain keto acid (BCKA) metabolism alters cardiac health. Here, the authors define the major fates of BCKA in the heart and demonstrate that acute exposure to BCKA levels found in obesity activates cardiac protein synthesis and markedly alters the heart phosphoproteome.

Jacquelyn M. Walejko
Bridgette A. Christopher
Robert W. McGarrah
ResearchOpen Access15 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Branched-chain amino acids in cardiovascular disease

In this Review, McGarrah and White outline the major factors regulating branched-chain amino acid (BCAA) abundance and metabolic fate, highlight molecular mechanisms connecting impaired BCAA homeostasis to cardiovascular disease and discuss the epidemiological evidence connecting BCAAs with various cardiovascular disease states.

Robert W. McGarrah
Phillip J. White
Reviews05 Sept 2022
Nature Reviews Cardiology

Volume: 20, P: 77-89
A saturated map of common genetic variants associated with human height

A large genome-wide association study of more than 5 million individuals reveals that 12,111 single-nucleotide polymorphisms account for nearly all the heritability of height attributable to common genetic variants.

Loïc Yengo
Sailaja Vedantam
Joel N. Hirschhorn
ResearchOpen Access12 Oct 2022
Nature

Volume: 610, P: 704-712
BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

The solute carrier transporter protein SLC25A44 regulates uptake of branched-chain amino acids in mitochondria of brown adipose tissue in which they are utilized for thermogenesis.

Takeshi Yoneshiro
Qiang Wang
Shingo Kajimura
Research21 Aug 2019
Nature

Volume: 572, P: 614-619
Novel plasma biomarkers improve discrimination of metabolic health independent of weight

Stephen Ellison
Jawan W. Abdulrahim
Svati H. Shah
ResearchOpen Access07 Dec 2020
Scientific Reports

Volume: 10, P: 1-9
Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes

Joseph B. Lerman
Stephanie N. Giamberardino
Robert W. McGarrah
ResearchOpen Access02 Jun 2022
Scientific Reports

Volume: 12, P: 1-11

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Polygenic prediction of body mass index and obesity through the life course and across ancestries

Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart

Branched-chain amino acids in cardiovascular disease

A saturated map of common genetic variants associated with human height

BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

Novel plasma biomarkers improve discrimination of metabolic health independent of weight

Plasma metabolites associated with functional and clinical outcomes in heart failure with reduced ejection fraction with and without type 2 diabetes

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