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An amphiphilic mimotope vaccine can be used in tandem with Food and Drug Administration (FDA)-approved CD19 CAR-T cell products.

Chronic care manages long-term, progressive conditions, while acute care handles short-term ones. Here, authors show chronic conditions account for most of the global health burden, with 68% of DALYs and 93% of YLDs attributed to chronic care needs.

The International Union for Pure and Applied Physics (IUPAP) celebrates its centenary this year, but its beginnings were far from easy. Roberto Lalli and Jaume Navarro reflect on IUPAP’s evolving role in promoting international cooperation.

The antiviral protein SP140 negatively regulates Ifnb1 mRNA stability by directly repressing the expression of the immune regulator RESIST.

Can science be a route to peace and common understanding? A glance at the history of one institution shows: only when scientists actively commit to it.

Genotype and exome sequencing of 150,000 participants and whole-genome sequencing of 9,950 selected individuals recruited into the Mexico City Prospective Study constitute a valuable, publicly available resource of non-European sequencing data.

JWST observations of a strongly lensed low-mass galaxy in a 600-million-year-old Universe show massive star clusters (the Firefly Sparkle) cocooned in a diffuse arc in the Canadian Unbiased Cluster Survey.

Geospatial estimates of the prevalence of anemia in women of reproductive age across 82 low-income and middle-income countries reveals considerable heterogeneity and inequality at national and subnational levels, with few countries on track to meet the WHO Global Nutrition Targets by 2030.

The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

Inborn errors of the alternative NF-κB pathway in humans impair the development of AIRE-expressing medullary thymic epithelial cells, thereby underlying the production of autoantibodies against type I IFNs and predisposition to viral diseases

Physical realizations of qubits are often vulnerable to leakage errors, where the system ends up outside the basis used to store quantum information. A leakage removal protocol can suppress the impact of leakage on quantum error-correcting codes.

Meta-analysis of genome-wide association studies on Alzheimer’s disease and related dementias identifies new loci and enables generation of a new genetic risk score associated with the risk of future Alzheimer’s disease and dementia.

High-resolution observations of early galaxies have shown that two-thirds are massive rotating disk galaxies with velocity dispersions typically five times higher than in today's galaxies. These authors report observations of a sample of rare, high-velocity-dispersion disk galaxies. They find that their velocity dispersions are correlated with their star formation rates, but not their masses or gas fractions, suggesting that star formation is the energetic driver of galaxy disk turbulence at all cosmic epochs.

Two below-threshold surface code memories on superconducting processors markedly reduce logical error rates, achieving high efficiency and real-time decoding, indicating potential for practical large-scale fault-tolerant quantum algorithms.

The dark-matter-free dwarf galaxies DF2 and DF4 in the NGC 1052 group probably formed together in the aftermath of a single bullet-dwarf collision around eight billion years ago.

The Omicron variant evades vaccine-induced neutralization but also fails to form syncytia, shows reduced replication in human lung cells and preferentially uses a TMPRSS2-independent cell entry pathway, which may contribute to enhanced replication in cells of the upper airway. Altered fusion and cell entry characteristics are linked to distinct regions of the Omicron spike protein.

A study demonstrating increasing error suppression with larger surface code logical qubits, implemented on a superconducting quantum processor.

Relatives of patients with amyotrophic lateral sclerosis have an unexpectedly high incidence of schizophrenia. Here, the authors show a genetic link between the two conditions, suggesting shared neurobiological mechanisms.

Astronomers can now peer far back in time, to redshifts of up toz= 4, and look at galaxies at different stages over 80-90 per cent of the total age of the Universe. A result is that the outline of a consensus about how galaxies form and evolve, as quantified by changes in star-formation rates, is emerging. A hierarchical picture best fits the evidence, one in which small, amorphous proto-galaxies form first, eventually settling into disk galaxies such as spirals, which can then also merge to form ellipticals.

Using chronic in vivo imaging of the mouse hippocampus over months, this study reveals aging-associated alterations of neural stem cells and their neuronal progeny that lead to reduced clonal output of individual neural stem cells with advancing age.

Galaxies normally have far more dark matter than normal matter, but the dynamics of objects within the ultra-diffuse galaxy NGC1052–DF2 suggest that it has a very little dark matter component.

General relativity underwent a conceptual transformation after World War II that can be used to understand the hitherto vaguely defined ‘renaissance of general relativity’, which led to the prediction and eventual discovery of gravitational waves.

Uchida and colleagues consider integration of information for perceptual decision making, focusing on olfactory and visual systems. They argue that there are neural mechanisms that construct discrete sensory samples from a continuous input stream to facilitate important computational functions.

A potent and selective catalytic inhibitor of p300/CBP histone acetyltransferases suppresses tumour proliferation across multiple cell lineages, illustrating the therapeutic potential of drug-like small molecules that target histone acetyltransferases.

An online, amendable classifier for detecting malaria parasite country of origin from genomic data is developed using a machine learning approach.

In an inter-laboratory study, the authors compare the accuracy and performance of three optical density calibration protocols (colloidal silica, serial dilution of silica microspheres, and colony-forming unit (CFU) assay). They demonstrate that serial dilution of silica microspheres is the best of these tested protocols, allowing precise and robust calibration that is easily assessed for quality control and can also evaluate the effective linear range of an instrument.