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Showing 1–6 of 6 results
Advanced filters: Author: Roberto Mallone Clear advanced filters

  • Interferon-α (IFN-α) is linked to type 1 diabetes (T1D), but how IFN-α impacts auto-antigen presentation is still unclear. Here the authors compare resting and IFN-α-treated islet β cells in vitro to find IFN-α inducing increased HLA-B expression, presentation of alternative epitopes, and activation of HLA-B-restricted T cells, thereby serving clues for T1D onset.

    • Alexia Carré
    • Fatoumata Samassa
    • Roberto Mallone
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-19

  • Detection of neoepitopes from tumours is time consuming and requires the integration of genomic and/or RNA sequencing expression data. Here, the authors propose a machine learning method to enable direct identification of additional, tumour-specific sequences using mass spectrometry through integration of de novo peptide sequencing scores, MHC class I binding prediction, and peptide retention time prediction.

    • Hanqing Liao
    • Carolina Barra
    • Nicola Ternette
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • The TYK2 gene is associated with development of type 1 diabetes. Here the authors show that TYK2 regulates β-cell development, but at the same time TYK2 inhibition in the islets prevents IFNα responses and enhances their survival against CD8+ T-cell cytotoxicity; representing a potent therapeutic target to halt T1D progression.

    • Vikash Chandra
    • Hazem Ibrahim
    • Timo Otonkoski
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Type 1 diabetes is driven by T-cell autoimmunity to pancreatic islet cells. Here the authors show that autoreactive anti-IL-2 T and B cells are present in type 1 diabetes patients, and that anti-IL-2 antibodies precede diabetes onset in mice, suggesting their potential as a diagnostic marker.

    • Louis Pérol
    • John M. Lindner
    • Eliane Piaggio
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • In type 1 diabetes, the immune system destroys pancreatic β-cells but not neighbouring α-cells. Here, the authors describe the key differences between β-cells and α-cells that could account for their differential autoimmune vulnerability, and how these differences could result in the preferential endurance and survival of α-cells over β-cells.

    • Decio L. Eizirik
    • Florian Szymczak
    • Roberto Mallone
    Reviews
    Nature Reviews Endocrinology
    Volume: 19, P: 425-434