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Showing 1–4 of 4 results
Advanced filters: Author: Roberto Maya-Martinez Clear advanced filters

  • The authors of this work characterize the effect of amino acid substitution on α-synuclein (α-Syn) aggregation. Residues 38 and 42 (in addition to 39) within the P1 region of α-Syn affect amyloid formation. The effect of substitution at position 38 is dependent on the amino-acid introduced, suggesting that specific interactions control α -Syn aggregation.

    • Sabine M. Ulamec
    • Roberto Maya-Martinez
    • David J. Brockwell
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Here the authors carry out chemical kinetic studies revealing that aggregation of hIAPP and its variant S20G involves secondary nucleation. Two small molecules with novel scaffolds are shown to inhibit or accelerate aggregation by binding different molecular species.

    • Yong Xu
    • Roberto Maya-Martinez
    • Sheena E. Radford
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • The authors use cryo-EM to determine amyloid fibrils structures of disease relevant variants of β2-microglobulin in vitro. Each variant is polymorphic, but all polymorphs from all samples are built from a a lego-like assembly of common building blocks, suggesting a one amyloid fold’ paradigm.

    • Martin Wilkinson
    • Rodrigo U. Gallardo
    • Neil A. Ranson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15