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Direct detection of an NH-π hydrogen bond in an intrinsically disordered peptide

The authors demonstrate a proof-of-principle example of an NH-π hydrogen bond on the surface of an intrinsically disordered protein through detection of weak scalar couplings by NMR, supported by Molecular Dynamics simulation and DFT calculations.

Luigi Russo
Dipendu Dhar
Nasrollah Rezaei-Ghaleh
ResearchOpen Access20 Nov 2025
Nature Communications

Volume: 16, P: 1-11
Large dynamics of a phase separating arginine-glycine-rich domain revealed via nuclear and electron spins

The authors show the RNA-induced droplet formation by a component of Cajal bodies and reveal the large nanoseconds mobility of glycine residues inside droplets as a molecular factor potentially contributing to the large dynamics of Cajal bodies.

Giuseppe Sicoli
Daniel Sieme
Nasrollah Rezaei-Ghaleh
ResearchOpen Access21 Feb 2024
Nature Communications

Volume: 15, P: 1-12
Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23

Structures of complete extracellular receptor assemblies mediated by the pro-inflammatory cytokines IL-12 and IL-23 reveal key commonalities and diverse features, with only IL-12 juxtaposing receptor domains proximal to the cell membrane.

Yehudi Bloch
Jan Felix
Savvas N. Savvides
Research29 Jan 2024
Nature Structural & Molecular Biology

Volume: 31, P: 591-597