Nature Search

Morphological transformation of human keratinocytes expressing the LMP gene of Epstein Barr virus

Robin Fhraeus
Lars Rymo
George Klein
Research31 May 1990
Nature

Volume: 345, P: 447-449
Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21^CDKN1A

DNA damage arrests the cell cycle in G1. Mlynarczyk et al.show that endoplasmic reticulum stress impairs DNA damage-induced p21 expression in favour of 14-3-3s-mediated G2 arrest by activating the p53 isoform p53/47, resulting in increased apoptosis in cells exposed to both stressors.

Coraline Mlynarczyk
Robin Fåhraeus
Research08 Oct 2014
Nature Communications

Volume: 5, P: 1-16
Has translation in the nucleus found its purpose?

Recent studies show that antigenic peptides are derived from the translation of precursor mRNAs. Robin Fåhraeus argues that it is therefore time to re-evaluate nuclear translation and its interesting implications.

Robin Fåhraeus
Comments & Opinion17 Aug 2023
Nature Reviews Molecular Cell Biology

Volume: 25, P: 1-2
p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

Yili Yin
Charles W. Stephen
Robin Fåhraeus
Research27 May 2002
Nature Cell Biology

Volume: 4, P: 462-467
A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47

Rhythm Sajwan
Lixiao Wang
Sivakumar Vadivel Gnanasundram
ResearchOpen Access26 Jul 2025
British Journal of Cancer

Volume: 133, P: 970-975
p53 mRNA controls p53 activity by managing Mdm2 functions

The ubiquitin ligase Mdm2 promotes both proteolytic degradation of the tumour suppressor p53 and its translation. Fahraeus and colleagues report an additional layer of regulation: p53 mRNA binds directly to Mdm2 protein to inhibit ubiquitin ligase activity, promoting its own translation.

Marco M. Candeias
Laurence Malbert-Colas
Robin Fåhraeus
Research10 Aug 2008
Nature Cell Biology

Volume: 10, P: 1098-1105
PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

The oncogenic activity of EBNA1 protein is unknown; it contains a glycine and alanine repeat sequence (GAr) which regulates its own translation in cis. Here the authors show that GAr stimulates PI3Kδ-mediated induction of E2F1 translation, leading to c-Myc induction and stimulation of proliferation.

Sivakumar Vadivel Gnanasundram
Slovénie Pyndiah
Robin Fåhraeus
ResearchOpen Access13 Dec 2017
Nature Communications

Volume: 8, P: 1-10
Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

Cells infected with Epstein-Barr virus (EBV) express the virus-encoded EBNA1, which is essential for viral genome maintenance but also highly antigenic. Here the authors implicate nucleolin as a host factor that mediates the repression of EBNA1-derived antigenic peptides through binding of the G4-quadruplex structure present within the EBNA1 mRNA.

María José Lista
Rodrigo Prado Martins
Marc Blondel
ResearchOpen Access07 Jul 2017
Nature Communications

Volume: 8, P: 1-13
Do peptides control their own birth and death?

Robin Fåhraeus
Reviews01 Mar 2005
Nature Reviews Molecular Cell Biology

Volume: 6, P: 263-267
Synthetic bacterial community derived from a desert rhizosphere confers salt stress resilience to tomato in the presence of a soil microbiome

Lucas Schmitz
Zhichun Yan
Xu Cheng
ResearchOpen Access20 Apr 2022
The ISME Journal

Volume: 16, P: 1907-1920
The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Leila Fusée
Norman Salomao
Robin Fahraeus
ResearchOpen Access22 Feb 2023
Cell Death & Differentiation

Volume: 30, P: 1072-1081
Thermal stress, p53 structures and learning from elephants

Konstantinos Karakostis
Monikaben Padariya
Fritz Vollrath
ReviewsOpen Access07 Aug 2024
Cell Death Discovery

Volume: 10, P: 1-5
Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

Xiaolian Gu
Linda Boldrup
Karin Nylander
ResearchOpen Access30 Aug 2016
Scientific Reports

Volume: 6, P: 1-8
Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

Robin Fåhraeus
Sonia Laín
David P Lane
Research16 Feb 1998
Oncogene

Volume: 16, P: 587-596
p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress

Ignacio López
Anne-Sophie Tournillon
Robin Fåhraeus
ResearchOpen Access16 Jun 2017
Cell Death & Differentiation

Volume: 24, P: 1717-1729
Whisper mutations: cryptic messages within the genetic code

R Fåhraeus
M Marin
V Olivares-Illana
Reviews14 Dec 2015
Oncogene

Volume: 35, P: 3753-3759
p53 binds the mdmx mRNA and controls its translation

A-S Tournillon
I López
R Fåhraeus
Research04 Jul 2016
Oncogene

Volume: 36, P: 723-730
p53 isoforms gain functions

V Olivares-Illana
R Fåhraeus
Reviews12 Jul 2010
Oncogene

Volume: 29, P: 5113-5119

Search

Morphological transformation of human keratinocytes expressing the LMP gene of Epstein Barr virus

Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21^CDKN1A

Has translation in the nucleus found its purpose?

p53 stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products

A cancer-associated TP53 synonymous mutation induces synthesis of the p53 isoform p53/47

p53 mRNA controls p53 activity by managing Mdm2 functions

PI3Kδ activates E2F1 synthesis in response to mRNA translation stress

Nucleolin directly mediates Epstein-Barr virus immune evasion through binding to G-quadruplexes of EBNA1 mRNA

Do peptides control their own birth and death?

Synthetic bacterial community derived from a desert rhizosphere confers salt stress resilience to tomato in the presence of a soil microbiome

The p53 endoplasmic reticulum stress-response pathway evolved in humans but not in mice via PERK-regulated p53 mRNA structures

Thermal stress, p53 structures and learning from elephants

Epigenetic regulation of OAS2 shows disease-specific DNA methylation profiles at individual CpG sites

Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule

p53-mediated suppression of BiP triggers BIK-induced apoptosis during prolonged endoplasmic reticulum stress

Whisper mutations: cryptic messages within the genetic code

p53 binds the mdmx mRNA and controls its translation

p53 isoforms gain functions

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