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Showing 1–6 of 6 results
Advanced filters: Author: Robinson Triboulet Clear advanced filters

  • Exportin-5 is involved in microRNA precursor nuclear export. Dicer mRNA is now found to compete with pre-miRNAs for exportin-5 binding, suggesting that cytoplasmic levels of Dicer and its pre-miRNA substrate engage in a feedback loop. Analysis of adenoviral RNA indicates that it can also compete for exportin-5, suggesting that this might be a mechanism by which adenovirus can interfere with host miRNA processing.

    • Yamina Bennasser
    • Christine Chable-Bessia
    • Monsef Benkirane
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 323-327

  • Here the authors show the exon junction complex (EJC) component, EIF4A3, locally restricts METTL3- mediated mRNA methylation at exon junctions to explain the observed widespread enrichment of m6A modification in 3’ untranslated regions.

    • Xin Yang
    • Robinson Triboulet
    • Richard I. Gregory
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3′ untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells.

    • Robinson Triboulet
    • Richard I. Gregory
    News & Views
    Nature Cell Biology
    Volume: 12, P: 928-929

  • This study shows that Dis3l2 is the 3′–5′ exonuclease that mediates the degradation of uridylated precursor let-7 microRNA; this is the first physiological RNA substrate identified for this new exonuclease, which causes the Perlman syndrome of fetal overgrowth and Wilms’ tumour susceptibility when mutated.

    • Hao-Ming Chang
    • Robinson Triboulet
    • Richard I. Gregory
    Research
    Nature
    Volume: 497, P: 244-248