Calmodulin (CaM) modulates the sarcoplasmic reticulum Ca2+ release channel, the ryanodine receptor (RyR), to facilitate Ca2+ cycling in muscle contraction and release. Using fluorescence lifetime FRET with native sarcoplasmic reticulum from skeletal and cardiac muscle, the authors resolve calcium-driven structural states and kinetics of CaM binding to RyR isoforms one and two.
- Robyn T. Rebbeck
- Bengt Svensson
- Razvan L. Cornea
