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Showing 1–2 of 2 results
Advanced filters: Author: Rocio Gomez-Pastor Clear advanced filters

  • Huntington’s disease (HD) is caused by misfolding of mutant Htt protein. The authors find that in HD models, the decreased expression of heat shock transcription factor 1 that usually protects against protein misfolding, is in part caused by elevated CK2α’ kinase and Fbxw7 E3 ligase expression.

    • Rocio Gomez-Pastor
    • Eileen T. Burchfiel
    • Dennis J. Thiele
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-17

  • Heat shock transcription factors (HSFs) regulate heat shock proteins in conditions of thermal stress, but they also control gene expression in other stress conditions, as well as in other contexts, including the regulation of cell proliferation and energy metabolism. HSFs are misregulated in various diseases, such as cancer and neurodegeneration, which underlines their important physiological roles.

    • Rocio Gomez-Pastor
    • Eileen T. Burchfiel
    • Dennis J. Thiele
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 19, P: 4-19