Whilst less than 5% of pituitary tumors are familial, identification of familial pituitary tumor syndromes is important owing to the associated pathologies that might occur and the important implications for family members. Advances have been made in our understanding of these syndromes in the past decade and four genes have now been identified as being associated with familial pituitary tumors:MEN1, CDKN1B, PRKAR1A and AIP. This article reviews the current state of knowledge of familial pituitary tumor syndromes.
- Marianne S. Elston
- Kerrie L. McDonald
- Bruce G. Robinson
