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Advanced filters: Author: Roderick Oosterwijk Clear advanced filters

Resolving sepsis-induced immunoparalysis via trained immunity by targeting interleukin-4 to myeloid cells

A nanoparticle integrating a fusion protein of apolipoprotein A1 and interleukin-4 and that targets myeloid-cell-rich haematopoietic organs resolves immunoparalysis in ex vivo and in vivo models of sepsis.

David P. Schrijver
Rutger J. Röring
Willem J. M. Mulder
ResearchOpen Access08 Jun 2023
Nature Biomedical Engineering

Volume: 7, P: 1097-1112
Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

A multimodal imaging approach using a high-density lipoprotein-derived nanotracer with a perfluoro-crown ether payload enables myeloid cell dynamics to be studied in vivo in mouse models of atherosclerosis and myocardial infarction.

Max L. Senders
Anu E. Meerwaldt
Willem J. M. Mulder
Research20 Apr 2020
Nature Nanotechnology

Volume: 15, P: 398-405
Macrophage PET imaging in mouse models of cardiovascular disease and cancer with an apolipoprotein-inspired radiotracer

Yohana C. Toner
Geoffrey Prévot
Carlos Pérez-Medina
ResearchOpen Access15 May 2024
npj Imaging

Volume: 2, P: 1-10