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Showing 1–10 of 10 results
Advanced filters: Author: Rodney Rothstein Clear advanced filters

  • Eukaryotic cells lacking telomerase activity can continue dividing using alternative mechanisms to maintain their telomeres (ALT). In yeast, such ALT cells are called survivors and amplify their telomeric DNA via recombination-based processes. Now a detailed analysis of survivors emerging from a senescent culture shows that these cells preferentially extend longer telomeres.

    • Michael Chang
    • John C Dittmar
    • Rodney Rothstein
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 451-456

  • The presence of DNA lesions is a clear signal that initiates the DNA damage response; however, the mechanisms that attenuate this response when repair has occurred are less clear. Here, deacetylation of Sae2 by Rpd3 and Hda1 is shown to be required for it to act on Mre11. When the role of Sae2 in resection is completed, it is acetylated by Gcn5 and degraded through an autophagic pathway. This work highlights links between DNA damage signalling, acetylation of repair factors, and autophagy mediated degradation of these factors.

    • Thomas Robert
    • Fabio Vanoli
    • Marco Foiani
    Research
    Nature
    Volume: 471, P: 74-79

  • Repair of double-strand breaks (DSBs) by homologous recombination is thought to involve the movement of damaged chromosomes to facilitate pairing of homologues. Rothstein and colleagues have now followed the movement of damaged loci in diploid yeast by time-lapse microscopy, revealing the dynamics of damage-induced movement and the requirement for repair proteins in this process.

    • Judith Miné-Hattab
    • Rodney Rothstein
    Research
    Nature Cell Biology
    Volume: 14, P: 510-517

  • DNA:RNA hybrids are linked to genetic instability in several pathological situations. Here, the authors report that various types of DNA lesions can trigger hybrid formation in yeast and humans, calling for a re-examination of the causality between these structures and genetic instability.

    • Raphaël M. Mangione
    • Steven Pierce
    • Benoit Palancade
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • In a large-scale analysis, the effects of DNA damage on the levels and localization of almost every protein in an organism have now been tracked in living cells. It is shown that that although many proteins change their position or concentration, they rarely do both.

    • Peter H. Thorpe
    • Rodney Rothstein
    News & Views
    Nature Cell Biology
    Volume: 14, P: 900-901