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Showing 1–6 of 6 results
Advanced filters: Author: Roel Bijkerk Clear advanced filters
  • Understanding dynamic metabolic changes in complex biological samples often overlooks heterogeneity in cell composition. Wang et al. combine mass spectrometry imaging, isotope tracing, and multiplexed immunofluorescence microscopy to study metabolic dynamics in the kidney upon ischemia–reperfusion.

    • Gangqi Wang
    • Bram Heijs
    • Ton J. Rabelink
    ResearchOpen Access
    Nature Metabolism
    Volume: 4, P: 1109-1118
  • Circulating non-coding RNAs (ncRNAs) are derived from specific cell types and can be directly transferred to a variety of cells to affect their function. This Review describes the relevance of circulating ncRNAs to the development of kidney disease and discusses the potential use of circulating ncRNAs as diagnostic factors and therapeutic targets.

    • Anton Jan van Zonneveld
    • Qiao Zhao
    • Roel Bijkerk
    Reviews
    Nature Reviews Nephrology
    Volume: 19, P: 573-586
  • Anton Jan van Zonneveld et al. study the role of miR-132 in the regulation of renin in the mouse. They demonstrate that miR-132 directly targets Cox-2 and subsequently affects PGE2 and renin levels. They perform a series of salt diet experiments as well as in vivo manipulations and show that miR-132 controls the steady-state levels of renin in a salt-dependent manner.

    • Anton Jan van Zonneveld
    • Yu Wah Au
    • Roel Bijkerk
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-11
  • CircRNAs have been implicated in the pathogenesis of kidney diseases, cardiovascular complications of chronic kidney disease and kidney cancer. This Review describes the roles of circRNAs in the pathophysiology of these diseases and highlights their potential as therapeutic targets and prognostic or diagnostic biomarkers.

    • Anton Jan van Zonneveld
    • Malte Kölling
    • Johan M. Lorenzen
    Reviews
    Nature Reviews Nephrology
    Volume: 17, P: 814-826