Nature Search

dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

Jasprien Noordermeer
John Klingensmith
Roel Nusse
Research06 Jan 1994
Nature

Volume: 367, P: 80-83
A new member of the frizzled family from Drosophila functions as a Wingless receptor

Purnima Bhanot
Marcel Brink
Roel Nusse
Research18 Jul 1996
Nature

Volume: 382, P: 225-230
Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

Frank van Leeuwen
Cynthia Harryman Samos
Roel Nusse
Research24 Mar 1994
Nature

Volume: 368, P: 342-344
Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

Roel Nusse
Albert van Ooyen
Harold Varmus
Research12 Jan 1984
Nature

Volume: 307, P: 131-136
Self-renewing diploid Axin2⁺ cells fuel homeostatic renewal of the liver

In the uninjured liver, a population of self-renewing, diploid hepatocytes is identified near the central vein; these cells respond to Wnt signals that are provided by the adjacent central vein endothelial cells, and can give rise to all other hepatocytes to maintain liver homeostasis.

Bruce Wang
Ludan Zhao
Roel Nusse
Research05 Aug 2015
Nature

Volume: 524, P: 180-185
Patching up Hedgehog

Roel Nusse
News & Views14 Nov 1996
Nature

Volume: 384, P: 119-120
A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma

Epigenetic causes of intra-tumoural heterogeneity are crucial in paediatric cancers with low mutation rates, such as hepatoblastoma. Here, the authors characterise transcriptional heterogeneity in hepatoblastoma using histology-guided RNA sequencing and functional studies in patient-derived tumoroids, and find how the embryonic biliary lineage program, Wnt, and paracrine signalling can promote tumour proliferation.

Peng V. Wu
Matt Fish
Roel Nusse
ResearchOpen Access20 Nov 2024
Nature Communications

Volume: 15, P: 1-19
A role for Wnt signalling in self-renewal of haematopoietic stem cells

Tannishtha Reya
Andrew W. Duncan
Irving L. Weissman
Research27 Apr 2003
Nature

Volume: 423, P: 409-414
Wnt proteins are lipid-modified and can act as stem cell growth factors

Karl Willert
Jeffrey D. Brown
Roel Nusse
Research27 Apr 2003
Nature

Volume: 423, P: 448-452
A new secreted protein that binds to Wnt proteins and inhibits their activites

Jen-Chih Hsieh
Laurent Kodjabachian
Jeremy Nathans
Research01 Apr 1999
Nature

Volume: 398, P: 431-436
WntD is a feedback inhibitor of Dorsal/NF-κB in Drosophila development and immunity

Michael D. Gordon
Marc S. Dionne
Roel Nusse
Research17 Aug 2005
Nature

Volume: 437, P: 746-749
The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

Sara Wilson
Anna Rydström
Thomas Edlund
Research01 May 2001
Nature

Volume: 411, P: 325-330
Disarming Wnt

The secreted enzyme Notum has been found to inhibit the Wnt signalling pathway through removal of a lipid that is linked to the Wnt protein and that is required for activation of Wnt receptor proteins. See Article p.187

Roel Nusse
News & Views25 Feb 2015
Nature

Volume: 519, P: 163-164
Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

Human embryonic stem cell cultures are morphologically heterogeneous. Here, differences in Wnt signalling are shown to contribute to this heterogeneity, cells containing high levels of Wnt form endodermal and cardiac cells, whereas cells with low Wnt form neuroectodermal cells, when differentiation is induced.

Timothy A. Blauwkamp
Shelly Nigam
Roel Nusse
ResearchOpen Access18 Sept 2012
Nature Communications

Volume: 3, P: 1-10
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Royal jelly is the queen-maker for the honey bee that also has effects on longevity, fertility, and regeneration in mammals. Here the authors provide evidence that its major protein component Royalactin, and the mammalian structural analog Regina, maintain pluripotency in mouse ESCs by activating a ground-state pluripotency-like gene network.

Derrick C. Wan
Stefanie L. Morgan
Kevin C. Wang
ResearchOpen Access04 Dec 2018
Nature Communications

Volume: 9, P: 1-9
Telomerase modulates Wnt signalling by association with target gene chromatin

The genetic pathways controlling stem cells are frequently dysregulated during tumorigenesis, with either stimulation of Wnt/β-catenin signalling or overexpression of telomerase sufficient to activate epidermal stem cells in vivo. Here, the telomerase protein component TERT (telomerase reverse transcriptase) is shown to have a role as a transcriptional modulator of the Wnt/β-catenin pathway, revealing a significant level of integration between the two pathways.

Jae-Il Park
Andrew S. Venteicher
Steven E. Artandi
Research02 Jul 2009
Nature

Volume: 460, P: 66-72
Wnt signalling sees spots

The organization of signalling complexes represents the coalescence of cell biology and signal transduction. Recent work on Dishevelled (Dvl), a multifunctional component of the Wnt–Frizzled (Fz) signalling pathway, ascribes vesicle- and actin-binding properties to a single domain within the protein. This could represent a critical point for divergence of the Wnt signalling pathway.

Michael Povelones
Roel Nusse
News & Views01 Nov 2002
Nature Cell Biology

Volume: 4, P: E249-E250
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

Premyelinating oligodendrocytes are vulnerable to hypoxic injuries, especially during the neonatal period. Here, Fancy et al. find that the Wnt scaffolding molecule Axin2 is crucial for normal remyelination after hypoxic injuries and demonstrate that pharmacological inhibition of tankyrase, which stabilizes Axin2 levels, can promote oligodendrocyte differentiation and recovery after hypoxic and demyelinating injuries.

Stephen P J Fancy
Emily P Harrington
David H Rowitch
Research26 Jun 2011
Nature Neuroscience

Volume: 14, P: 1009-1016
Relays at the membrane

The Wnt signalling pathway is a major route by which the cell conveys information from its exterior to the nucleus. A gap in the sequence of signalling proteins has now been filled.

Roel Nusse
News & Views07 Dec 2005
Nature

Volume: 438, P: 747-749
Making head or tail of Dickkopf

Signals that guide embryonic cells through development are often under the control of inhibitors. It now seems that one such inhibitor does not bind to the signal itself, but rather to the receptor that detects the signal.

Roel Nusse
News & Views01 May 2001
Nature

Volume: 411, P: 255-256
Molecular hallmarks of heterochronic parabiosis at single-cell resolution

A transcriptomics study demonstrates cell-type-specific responses to differentially aged blood and shows young blood to have restorative and rejuvenating effects that may be invoked through enhanced mitochondrial function.

Róbert Pálovics
Andreas Keller
Tony Wyss-Coray
Research02 Mar 2022
Nature

Volume: 603, P: 309-314
Creating transgenic Drosophila by microinjecting the site-specific φC31 integrase mRNA and a transgene-containing donor plasmid

Matthew P Fish
Amy C Groth
Roel Nusse
Protocols20 Sept 2007
Nature Protocols

Volume: 2, P: 2325-2331
A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

A single-cell transcriptomic atlas across the lifespan of the mouse, denoted Tabula Muris Senis, provides molecular information about the hallmarks of ageing in a range of tissues and cell types.

Nicole Almanzar
Jane Antony
James Zou
Research15 Jul 2020
Nature

Volume: 583, P: 590-595
WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

Lorenza Ciani
Patricia C. Salinas
Reviews15 Apr 2005
Nature Reviews Neuroscience

Volume: 6, P: 351-362
Ageing hallmarks exhibit organ-specific temporal signatures

Bulk RNA sequencing of organs and plasma proteomics at different ages across the mouse lifespan is integrated with data from the Tabula Muris Senis, a transcriptomic atlas of ageing mouse tissues, to describe organ-specific changes in gene expression during ageing.

Nicholas Schaum
Benoit Lehallier
Tony Wyss-Coray
Research15 Jul 2020
Nature

Volume: 583, P: 596-602
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

A ‘mouse atlas’, comprising single-cell transcriptomic data from more than 100,000 cells from 20 organs and tissues, has been created as a resource for cell biology.

Nicholas Schaum
Jim Karkanias
Tony Wyss-Coray
Research03 Oct 2018
Nature

Volume: 562, P: 367-372
Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

ten Berge and colleagues show that Wnt signalling is required for self-renewal of embryonic stem cells through inhibition of their differentiation into epiblast stem cells. Together, Wnt and LIF signalling can support derivation and self-renewal of embryonic stem cells.

Derk ten Berge
Dorota Kurek
Roel Nusse
Research14 Aug 2011
Nature Cell Biology

Volume: 13, P: 1070-1075
Wnt signaling in disease and in development

Roel NUSSE
Reviews01 Jan 2005
Cell Research

Volume: 15, P: 28-32
Wnt signaling and stem cell control

Roel Nusse
Reviews08 Apr 2008
Cell Research

Volume: 18, P: 523-527
Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

Identifying genes that are essential for maintaining neuronal integrity provides significant insight into the mechanisms underlying neurodegenerative disorders. Recessive mutants in the fly have proven invaluable for finding such genes and for highlighting key biological processes that contribute to neurodegeneration.

Derek Lessing
Nancy M. Bonini
Reviews01 Jun 2009
Nature Reviews Genetics

Volume: 10, P: 359-370

Search

dishevelled and armadillo act in the Wingless signalling pathway in Drosophila

A new member of the frizzled family from Drosophila functions as a Wingless receptor

Biological activity of soluble wingless protein in cultured Drosophila imaginal disc cells

Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15

Self-renewing diploid Axin2⁺ cells fuel homeostatic renewal of the liver

Patching up Hedgehog

A developmental biliary lineage program cooperates with Wnt activation to promote cell proliferation in hepatoblastoma

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Wnt proteins are lipid-modified and can act as stem cell growth factors

A new secreted protein that binds to Wnt proteins and inhibits their activites

WntD is a feedback inhibitor of Dorsal/NF-κB in Drosophila development and immunity

The status of Wnt signalling regulates neural and epidermal fates in the chick embryo

Disarming Wnt

Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors

Honey bee Royalactin unlocks conserved pluripotency pathway in mammals

Telomerase modulates Wnt signalling by association with target gene chromatin

Wnt signalling sees spots

Axin2 as regulatory and therapeutic target in newborn brain injury and remyelination

Relays at the membrane

Making head or tail of Dickkopf

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Creating transgenic Drosophila by microinjecting the site-specific φC31 integrase mRNA and a transgene-containing donor plasmid

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

WNTS in the vertebrate nervous system: from patterning to neuronal connectivity

Ageing hallmarks exhibit organ-specific temporal signatures

Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris

Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells

Wnt signaling in disease and in development

Wnt signaling and stem cell control

Maintaining the brain: insight into human neurodegeneration from Drosophila melanogaster mutants

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