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Showing 1–8 of 8 results
Advanced filters: Author: Roel P. H. De Maeyer Clear advanced filters

  • Human aging is characterized by an elevated basal inflammatory state. Gilroy and colleagues use a tractable in vivo human inflammation model to demonstrate a mechanism whereby efferocytosis is impaired in the elderly but is reversible by p38 inhibition.

    • Roel P. H. De Maeyer
    • Rachel C. van de Merwe
    • Derek W. Gilroy
    Research
    Nature Immunology
    Volume: 21, P: 615-625

  • Akbar and colleagues show that sestrins induce the reprogramming of non-proliferative, senescent-like CD27–CD28–CD8+ T cells to acquire an innate-like killing activity modulated by the NK receptor NKG2D and the adaptor molecule DAP12.

    • Branca I. Pereira
    • Roel P. H. De Maeyer
    • Arne N. Akbar
    Research
    Nature Immunology
    Volume: 21, P: 684-694

  • The post-resolution phase of inflammation is not simply a linear path towards cessation of immune response but rather a regulated process involving fluctuating immune activity. Here authors show a pivotal role for post-resolution macrophages in driving a wave of T cell recruitment and activation via prostaglandin E2 and α-integrin signalling during the resolution phase of murine pneumococcal pneumonia.

    • Karen T. Feehan
    • Hannah E. Bridgewater
    • Derek W. Gilroy
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Immune dysfunction increases with age owing to cellular senescence and low-grade inflammation, processes that drive each other during ageing. This Review discusses the potential of therapeutic approaches that target interactions between the tissue environment and the immune system by eliminating senescent cells, inhibiting inflammation and boosting immune function.

    • Olivia V. Bracken
    • Roel P. H. De Maeyer
    • Arne N. Akbar
    Reviews
    Nature Reviews Drug Discovery
    Volume: 24, P: 300-315

  • Frailty is an important age-related prognostic for mortality, and little is known about its immune landscape. Luo et al.1 use single-cell profiling to gather a comprehensive understanding of immune changes that happen from birth to old age, and provide new insights into the often-overlooked state of frailty.

    • Roel P. H. De Maeyer
    • Arne N. Akbar
    News & Views
    Nature Aging
    Volume: 2, P: 280-281

  • The clearance of dying cells by macrophages releases mediators that switch off inflammation. Ampomah et al. reveal how an amino acid derived from apoptotic cargo changes the methylation epigenome of macrophages to take the brakes off an ERK-dependent pathway that terminates inflammatory responses.

    • Roel P. H. De Maeyer
    • Derek W. Gilroy
    News & Views
    Nature Metabolism
    Volume: 4, P: 414-415