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Showing 1–4 of 4 results
Advanced filters: Author: Roeland M. H. Merks Clear advanced filters

  • The authors use a long-term evolve-and-resequence experiment in the flour beetle Tribolium castaneum to identify the genetic basis for variation in development time, finding that a deletion upstream of the enzyme Cyp18a1 is a main target of selection, and this allele accelerates development but trades off with fecundity.

    • Shixiong Cheng
    • Chris G. C. Jacobs
    • Maurijn van der Zee
    Research
    Nature Ecology & Evolution
    Volume: 8, P: 70-82

  • Cell shape influences function but during mitotic cell rounding the original shape is lost. Here the authors show that the cellular eccentricity of progenitor cell biases stochastic fate-decisions using a combination of quantitative live imaging, genetic manipulations and computational simulations.

    • Takashi Akanuma
    • Cong Chen
    • Thomas N. Sato
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-17

  • Glycolytic regulator PFKFB3 is a key player in vessel sprouting. Here the authors develop a computational model predicting that PFKFB3 drives endothelial cell rearrangement during vessel sprouting by promoting filopodia formation and reducing intercellular adhesion, and empirically validate this prediction.

    • Bert Cruys
    • Brian W. Wong
    • Peter Carmeliet
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-15