The endocannabinoid 2-AG is produced by the enzyme diacylglycerol lipase (DGL). The authors show that DGLα is phosphorylated and inhibited by calcium/calmodulin–dependent protein kinase II (CaMKII). Inhibition of CaMKII activity increases striatal DGL activity and basal 2-AG amounts, and augments short-term retrograde endocannabinoid signaling at striatal glutamatergic synapses.
- Brian C Shonesy
- Xiaohan Wang
- Roger J Colbran
