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Showing 1–8 of 8 results
Advanced filters: Author: Roger R Markwald Clear advanced filters

  • Collaboration between clinicians and basic scientists is vital for effective bench-to-bedside research translations, but the interdependent nature of the two professions is currently underemphasized. Cardiovascular developmental biology in particular has important implications for our understanding of adult disease processes. Here Roger Markwald and Jonathan Butcher discuss key discoveries in developmental biology that have the potential to impact the diagnosis and treatment of adult cardiac disease, and appeal to clinicians and basic scientists alike to improve dialogue and learn from each other.

    • Roger R Markwald
    • Jonathan T Butcher
    Reviews
    Nature Clinical Practice Cardiovascular Medicine
    Volume: 4, P: 60-61

  • There are few human models that can recapitulate valve development in vitro. Here, the authors derive human pre-valvular endocardial cells (HPVCs) from iPSCs and show they can recapitulate early valvulogenesis, and patient derived HPVCs have features of mitral valve prolapse and identified SHH dysregulation.

    • Tui Neri
    • Emilye Hiriart
    • Michel Pucéat
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Mitral valve disease is a common cause of heart failure and death. In this Review from members of the Leducq Transatlantic Network, Levine and colleagues extensively summarize the molecular and cellular mechanisms underlying the dynamic changes that occur during progression of mitral valve disease, and indicate how improved understanding of the pathophysiology might lead to the discovery of novel therapeutic options.

    • Robert A. Levine
    • Albert A. Hagége
    • Magdi H. Yacoub
    Reviews
    Nature Reviews Cardiology
    Volume: 12, P: 689-710

  • Christian Dina, Nabila Bouatia-Naji, Xavier Jeunemaitre and colleagues from the Leducq Transatlantic MITRAL Network report the results of a genome-wide association study of nonsyndromic mitral valve prolapse. They identify six susceptibility loci and provide functional evidence implicating LMCD1 and TNS1 as genes influencing mitral valve development.

    • Christian Dina
    • Nabila Bouatia-Naji
    • Xavier Jeunemaitre
    Research
    Nature Genetics
    Volume: 47, P: 1206-1211

  • Two mutations in the gene DCHS1 are shown to cause non-syndromic mitral valve prolapse (MVP), a common cardiac valve disease; understanding the role of DCHS1 in mitral valve development and MVP pathogenesis holds therapeutic potential.

    • Ronen Durst
    • Kimberly Sauls
    • Susan A. Slaugenhaupt
    Research
    Nature
    Volume: 525, P: 109-113