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Showing 1–4 of 4 results

Advanced filters: Author: Rohan N. Krajeski Clear advanced filters

Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases

Large sequences are integrated site specifically into the human genome without double-strand DNA cleavage.

Matthew T. N. Yarnall
Eleonora I. Ioannidi
Jonathan S. Gootenberg
Research24 Nov 2022
Nature Biotechnology

Volume: 41, P: 500-512
Reprogramming site-specific retrotransposon activity to new DNA sites

A study of retrotransposon activity repurposes a retroelement called R2Tocc to create a programmable system called STITCHR that enables diverse genome edits including efficient, scarless large payload insertions.

Christopher W. Fell
Lukas Villiger
Jonathan S. Gootenberg
Research09 Apr 2025
Nature

Volume: 642, P: 1080-1089
Programmable eukaryotic protein synthesis with RNA sensors by harnessing ADAR

An RNA sensor harnesses ADAR to control translation of a target protein.

Kaiyi Jiang
Jeremy Koob
Omar O. Abudayyeh
Research27 Oct 2022
Nature Biotechnology

Volume: 41, P: 698-707
Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

Cas7-11—the fusion of a putative Cas11 domain and four Cas7 subunits—cleaves RNA without detectable non-specific activity and, when optimized for RNA knockdown and editing in mammalian cells, has no effects on cell viability.

Ahsen Özcan
Rohan Krajeski
Jonathan S. Gootenberg
Research06 Sept 2021
Nature

Volume: 597, P: 720-725