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Showing 1–9 of 9 results
Advanced filters: Author: Rohan T. Ranasinghe Clear advanced filters

  • α-synuclein aggregates cause neuronal damage, but their heterogeneity complicates studying their toxic properties. Here, the authors analyze α-synuclein aggregates in vitro and study post-mortem brain samples, providing evidence that small aggregates are the main culprit for neuronal death in Parkinson’s disease.

    • Derya Emin
    • Yu P. Zhang
    • David Klenerman
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Visualization of endogenous G-quadruplexes (G4s) in living cells by fluorescence microscopy has been hampered by the high concentrations of G4-binding probes required, which can artificially induce additional G4 formation. Now, a G4-specific fluorescent probe (SiR-PyPDS) has been developed that enables single-molecule and real-time detection of individual G4 structures in living cells without perturbing G4 formation and dynamics.

    • Marco Di Antonio
    • Aleks Ponjavic
    • Shankar Balasubramanian
    Research
    Nature Chemistry
    Volume: 12, P: 832-837

  • Methylated RNA bases influence many life processes, but current detection methods lack the ability to detect individual methylations in single cells. Here, the authors use fluorescence hybridization probes sensitive to methylation to detect specific epitranscriptomic modifications at the single-cell level.

    • Rohan T. Ranasinghe
    • Martin R. Challand
    • David Klenerman
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-10

  • How toxic aggregated forms of α-synuclein lead to neurodegeneration is unclear. Here authors use biophysical and cellular imaging methods to show that specific oligomers of α-synuclein exert effects on mitochondria to induce opening of the permeability transition pore, leading to cell death in Parkinson’s disease.

    • Marthe H. R. Ludtmann
    • Plamena R. Angelova
    • Sonia Gandhi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Many super-resolution imaging techniques use fluorescence emission intensity to obtain precise positional information, but other spectral information is ignored. Here, the authors develop a method that records the spectrum and position of single dye molecules to map the hydrophobicity of a surface.

    • Marie N. Bongiovanni
    • Julien Godet
    • Steven F. Lee
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Jason Sang et al. use super-resolution microscopy to monitor α-synuclein aggregation and uptake in SH-SY5Y neuroblastoma cells. Their results suggest that cells secrete nanoscopic aggregates in response to disruption of protein homeostasis by these α-synuclein seeds, and may represent a protective response by cells to protein aggregation.

    • Jason C. Sang
    • Eric Hidari
    • David Klenerman
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11