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Showing 1–4 of 4 results

Advanced filters: Author: Rohit A. Panchakshari Clear advanced filters

CGRP-related neuropeptide adrenomedullin 2 promotes tissue-protective ILC2 responses and limits intestinal inflammation

Artis and colleagues show that enteric neurons produce CGRP-related ADM2 to promote intestinal tissue-protective functions in ILC2s.

Jazib Uddin
Hiroshi Yano
David Artis
Research15 Aug 2025
Nature Immunology

Volume: 26, P: 1516-1526
Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching

High-throughput genome-wide sequencing reveals why class switch recombination in the IgH locus, an essential step in the process of antibody generation, has a directional joining bias towards deletion rather than inversion.

Junchao Dong
Rohit A. Panchakshari
Frederick W. Alt
Research26 Aug 2015
Nature

Volume: 525, P: 134-139
Microbial colonization influences early B-lineage development in the gut lamina propria

Primary B-cell development is thought to be restricted to the bone marrow; here it is shown to occur also in intestinal tissues of postnatal mice, that it peaks at the time of weaning and is increased upon colonization of germ-free mice, and is thus influenced by commensal microbes.

Duane R. Wesemann
Andrew J. Portuguese
Frederick W. Alt
Research21 Aug 2013
Nature

Volume: 501, P: 112-115
Detecting DNA double-stranded breaks in mammalian genomes by linear amplification–mediated high-throughput genome-wide translocation sequencing

This protocol describes a genome-wide method to detect and to quantify DNA double-stranded breaks (DSBs). The approach is applicable to endogenous DSBs, but it can also be used to characterize the activity of engineered nucleases, including Cas9.

Jiazhi Hu
Robin M Meyers
Richard L Frock
Protocols31 Mar 2016
Nature Protocols

Volume: 11, P: 853-871