Nature Search

Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes

Here, the authors link early immune cell hypoxia signatures to typhoid disease development in humans and, using mouse models, show that this immune response is triggered by Salmonella gut invasion, implicating a causal role in typhoid fever pathogenesis.

Noa Bossel Ben-Moshe
Shelly Hen-Avivi
Roi Avraham
ResearchOpen Access22 Jul 2025
Nature Communications

Volume: 16, P: 1-19
Generation of specialized blood vessels via lymphatic transdifferentiation

A study of zebrafish identifies an innate mechanism of blood vessel formation through the transdifferentiation of lymphatic endothelial cells, and provides in vivo evidence for a link between cell ontogeny and functionality in endothelial cells.

Rudra N. Das
Yaara Tevet
Karina Yaniv
Research25 May 2022
Nature

Volume: 606, P: 570-575
Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells

Complex interactions between different host immune cell types can determine the outcome of pathogen infections. Here, Avraham and colleagues present a deconvolution algorithm that uses single-cell RNA and bulk RNA sequencing measurements of pathogen-infected cells to predict disease risk outcomes.

Noa Bossel Ben-Moshe
Shelly Hen-Avivi
Roi Avraham
ResearchOpen Access22 Jul 2019
Nature Communications

Volume: 10, P: 1-16
Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization

Theresa V. Rohm
Felipe Castellani Gomes Dos Reis
Jerrold M. Olefsky
Amendments and Corrections05 Jul 2024
Nature Metabolism

Volume: 6, P: 1646
Boycotting academics in Israel is counterproductive

Simone Shamay-Tsoory
Mouna Maroun
Shir Atzil
Correspondence18 Jun 2024
Nature

Volume: 630, P: 563
A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes

This protocol enables simultaneous analysis of host and bacterial transcripts by RNA-seq. It includes procedures for efficient host and bacterial cell lysis, barcoding of samples and analysis of both mammalian and microbial reads from mixed host–pathogen RNA-seq data.

Roi Avraham
Nathan Haseley
Deborah T Hung
Protocols21 Jul 2016
Nature Protocols

Volume: 11, P: 1477-1491
Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization

Rohm et al. show that small extracellular vesicles from adipose tissue macrophages from obese rosiglitazone-treated mice ameliorate glucose tolerance and insulin sensitivity in obese mice, while circumventing the adverse effects of rosiglitazone.

Theresa V. Rohm
Felipe Castellani Gomes Dos Reis
Jerrold M. Olefsky
Research11 Apr 2024
Nature Metabolism

Volume: 6, P: 880-898
Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Jacob Hanna
Debra Goldman-Wohl
Ofer Mandelboim
Research06 Aug 2006
Nature Medicine

Volume: 12, P: 1065-1074
Immunometabolic crosstalk during bacterial infection

Following bacterial infection, macrophages undergo metabolic changes that activate antibacterial responses. However, pathogens can exploit host immunometabolites as a signal for virulence induction. This Review examines the crosstalk between pathogens and macrophage immunometabolism.

Gili Rosenberg
Sebastian Riquelme
Roi Avraham
Reviews01 Apr 2022
Nature Microbiology

Volume: 7, P: 497-507
Feedback regulation of EGFR signalling: decision making by early and delayed loops

The ability of growth factors and receptor Tyr kinases of the epidermal growth factor receptor (EGFR)/ERBB family to regulate cellular function is controlled by positive and negative feedback loops. These can decode ligand specificity, transform graded inputs into digital outputs and regulate response kinetics. Aberrant feedback can lead to pathologies, including cancer.

Roi Avraham
Yosef Yarden
Reviews21 Jan 2011
Nature Reviews Molecular Cell Biology

Volume: 12, P: 104-117
A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration

Menachem Katz
Ido Amit
Yosef Yarden
Research22 Jul 2007
Nature Cell Biology

Volume: 9, P: 961-969
Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis

Viktoria Betin
Cristina Penaranda
Deborah T. Hung
ResearchOpen Access17 Dec 2019
Scientific Reports

Volume: 9, P: 1-13

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Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes

Generation of specialized blood vessels via lymphatic transdifferentiation

Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells

Author Correction: Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization

Boycotting academics in Israel is counterproductive

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes

Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Immunometabolic crosstalk during bacterial infection

Feedback regulation of EGFR signalling: decision making by early and delayed loops

A reciprocal tensin-3–cten switch mediates EGF-driven mammary cell migration

Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis

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